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228 points curmudgeon22 | 204 comments | | HN request time: 1.525s | source | bottom
1. maxrev17 ◴[] No.26612281[source]
Be interested to see a percentage increase in fat burning (I.e. is it worth nailing a coffee or not if you are a big fat coder looking to shift a few pounds)
replies(4): >>26612331 #>>26612354 #>>26612386 #>>26613326 #
2. softwaredoug ◴[] No.26612295[source]
I’ve always avoided caffeine before exercise because I’ve worried about overexerting myself and getting an injury from going all out. I wonder if there’s research on this factor?
replies(7): >>26612317 #>>26612424 #>>26612438 #>>26612732 #>>26612845 #>>26612881 #>>26615713 #
3. TwoBit ◴[] No.26612315[source]
I haven't read this study, but I read about this from other studies 20 years ago.
replies(1): >>26612367 #
4. bluedino ◴[] No.26612317[source]
Caffeine is the main ingredient in most pre-workout drinks
5. jonnycomputer ◴[] No.26612323[source]
"15 caffeine-naive men" mean age 32 years.

Now we know why the N is so low. /s

replies(1): >>26616995 #
6. dbsmith83 ◴[] No.26612331[source]
There is a link to the study at the bottom

> MFO, Fatmax and VO2max were significantly higher in the afternoon than in the morning (all P < 0.05). Compared to the placebo, caffeine increased mean MFO by 10.7% (0.28 ± 0.10 vs. 0.31 ± 0.09 g/min respectively, P < 0.001) in the morning, and by a mean 29.0% (0.31 ± 0.09 vs. 0.40 ± 0.10 g/min, P < 0.001) in the afternoon. Caffeine also increased mean Fatmax by 11.1% (36.9 ± 14.4 [placebo] vs. 41.0 ± 13.1%, P = 0.005) in the morning, and by 13.1% (42.0 ± 11.6 vs. 47.5 ± 10.8%, P = 0.008) in the afternoon.

7. beforeolives ◴[] No.26612336[source]
This has been known for a long time and it's fairly well studied. I suppose the more interesting part for them was studying the daily variation in fat burning.
8. jonnycomputer ◴[] No.26612354[source]
From paper's abstract:

>Compared to the placebo, caffeine increased mean MFO by 10.7%

https://jissn.biomedcentral.com/articles/10.1186/s12970-020-...

9. baby ◴[] No.26612362[source]
Or can give you a heart attack no?
10. PragmaticPulp ◴[] No.26612365[source]
> Subjects ingested 3 mg/kg of caffeine or a placebo at 8am and 5pm

3mg/kg is over 250mg of caffeine for an average weight man. Twice a day makes that 500mg.

An 8.4oz can of Red Bull contains 80mg of caffeine. They were giving these people an amount of caffeine equivalent to 6 cans of Red Bull. Not a perfect comparison because Red Bull contains other ingredients, but that's still a lot of caffeine. For another point of reference, that's 2.5 shots of 5 hour energy (200mg caffeine per bottle).

To top it off, the subjects were caffeine-naive, so they had no caffeine tolerance. They must have been feeling extremely energetic.

No wonder they burned more fat. I'm not sure this is going to translate to your casual coffee drinker or someone with a high caffeine tolerance.

replies(16): >>26612399 #>>26612440 #>>26612446 #>>26612494 #>>26612558 #>>26612565 #>>26612569 #>>26612587 #>>26612607 #>>26612655 #>>26612813 #>>26612954 #>>26613385 #>>26613894 #>>26616191 #>>26623345 #
11. webmaven ◴[] No.26612367[source]
> I haven't read this study, but I read about this from other studies 20 years ago.

A few years ago I saw an EMEA advertising campaign promoting Turkish coffee as a pre-exercise boost.

12. dbsmith83 ◴[] No.26612371[source]
The article title is misleading since the participants didn't actually drink coffee. I know, they said they ingested caffeine 'equivalent to', but it's a little misleading. There are other compounds in coffee which could increase or decrease the effects of just caffeine so it's best to not just assume it would be the same.
13. _0qft ◴[] No.26612373[source]
anti depressants also makes you quite sensitive to caffeine
14. kec ◴[] No.26612386[source]
Exercise is great for general fitness and can give you a slight edge in a calorie deficit but has little impact on weight loss in general. If you want to lose weight by far the easiest and most effective thing you can do is to get your diet under control.
replies(4): >>26612419 #>>26612434 #>>26612484 #>>26615258 #
15. oatmale ◴[] No.26612390[source]
Kind of old news at this point right? It’s been touted as a “life hack” for at least a decade. I remember reading about this in the four hour body book. That was published in 2010. It was also based on prior studies.
16. watwut ◴[] No.26612399[source]
Yet another question is, whether or is even healthy. It might just be that not burning that fat more quickly can be healthier then drinking so much coffein.
17. bArray ◴[] No.26612411[source]
I believe this is the paper: https://jissn.biomedcentral.com/track/pdf/10.1186/s12970-020...

Seems as though we're talking about MFO (maximal fat oxidization) of 10.7% in the morning and 29% in the afternoon. Interestingly you see an increase in VO2max as well - which I believe is essentially blood oxygen.

A few things I'll point out though:

1. This is just 15 men, aged 32 +/- 7 years. Doesn't quite seem like enough people to definitively draw a conclusion.

2. They are described as 'caffeine-naïve' (which I assume means they do not normally consume caffeine) - so it's unclear if this effect would be the same to somebody who already regularly drinks caffeine.

18. watwut ◴[] No.26612419{3}[source]
However, exercise is very important ingredient if your goal is health rather then aesthetic.
replies(1): >>26612622 #
19. ve55 ◴[] No.26612423[source]
My favorite thing about 'study finds' articles on HN is that I get to read the comments and see people instantly tell me why the article (or sometimes paper as well) is terrible.

I mean this sincerely too, since it's a very low-effort and quick way to find what is often some pretty critical flaws in the presented conclusions.

replies(5): >>26612611 #>>26612707 #>>26612791 #>>26613123 #>>26619935 #
20. dbsmith83 ◴[] No.26612424[source]
I do too for the most part. It seems too risky and I am not a professional athlete, so there is no need to push it too hard.

https://aaptiv.com/magazine/pre-workout-drinks "Are Pre-Workout Drinks Healthy or Harmful?" > The caffeine and creatine that most of these drinks contain can also have harmful effects on the body. “Excessive caffeine can increase your heart rate and blood pressure, causing cardiac issues,” Woeckener notes.

21. randlet ◴[] No.26612434{3}[source]
> If you want to lose weight by far the easiest and most effective thing you can do is to get your diet under control.

Easy is the wrong word. Getting your diet under control is the hardest part of losing weight. Most effective, absolutely. Simple, yes, easy, no.

replies(3): >>26612525 #>>26612887 #>>26613387 #
22. melolife ◴[] No.26612438[source]
This is the last thing I'd be worried about. It's coffee, not some kind of anabolic steroid/cocaine mixture.

I know a lot of people who spend way too much time trying to optimize supplements and other tiny details instead of throwing down and getting on with your life.

Edit: after reading other comments yours makes more sense, but I'd still be more worried about what's actually in a pre-work out beverage than over-exertion.

23. snarfy ◴[] No.26612440[source]
3mg/kg for an average weight man is about 3 cups of coffee.
24. rubyn00bie ◴[] No.26612442[source]
This is not surprising to anyone who has ever walked into a GNC, or other health food store... is it even news? They’ve been selling shit like “redline” for many years to do exactly this.

Power fat burner: caffeine + blood thinner. That’s most of what things like redline do. Is it going to work if you don’t exercise? Nope, but it sure as hell does help if you are exercising.

I’d really only recommend it to people focused on losing a lot of weight. If you’re trying to lose 10lbs it’ll never make a difference. If you’re trying to lose 100lbs though, then yeah, 6-12 months worth of slightly increased metabolic rate will probs have a net positive affect.

replies(6): >>26612495 #>>26612694 #>>26613029 #>>26613173 #>>26613275 #>>26615156 #
25. themolecularman ◴[] No.26612446[source]
Interestingly I've heard about a strong relationship between heart attacks and consumption of energy drinks like Monster/Red-Bull.

I used to drink a lot of Red Bull and stopped as a result. But I sometimes think one of the reasons I haven't put on weight despite my lifestyle is because of my caffeine habits.

replies(3): >>26612657 #>>26612829 #>>26612846 #
26. dbsmith83 ◴[] No.26612484{3}[source]
I've lost significant weight twice (~20-25 lbs). Once was purely diet with very little exercise, and the other way was way more exercise, but less diet control.

The first way made me feel tired and light-headed, and not that great overall. The second way (high exercise, a little diet control) took longer, but also makes me feel 10 years younger and pretty much as healthy as I've ever been.

replies(2): >>26612574 #>>26613014 #
27. lmilcin ◴[] No.26612494[source]
I am pretty sure that not sleeping at all also increases fat burning as body uses less energy when asleep

The fat burning might be from reaction of organism that is not used to a lot of daily caffeine ingestion. For example, when I don't use caffeine for a long time my heart rate increases when I increase amount of coffee I drink. But then goes back after some time (presumably when my body gets accustomed to it again).

Also, this kind of research must be read with a little bit of scientific background.

It is easy to get an impression author wanted to establish causation, but in reality this research only shows correlation, and correlation does not prove causation.

replies(2): >>26612594 #>>26612610 #
28. robbintt ◴[] No.26612495[source]
What is the blood thinner for?

Edit: found this ingredient list but not sure if it is the same formulation or what I am looking for: https://www.heb.com/product-detail/vpx-redline-xtreme-triple...

replies(1): >>26612774 #
29. amelius ◴[] No.26612501[source]
But coffee induces stomach acid reflux, which is definitely not what you want during exercise, so catch-22 here.
30. mmartinson ◴[] No.26612525{4}[source]
I’ve always found exercise to be a motivator for getting diet under control. Periods of low exercise correlates with bad eating. Building back the routine makes shifting diet much easier.
replies(2): >>26613109 #>>26615285 #
31. raverbashing ◴[] No.26612558[source]
Yeah one can is my limit (let's say, for a 4h period). I can't imagine what would feel taking the equivalent of taking that amount all at once. Probably the usual effects (headache and severe dizziness)

That being said, caffeine is a good pre-workout.

32. perrylaj ◴[] No.26612565[source]
Seems like a lot when put in terms of Redbull, but isn't really in the context of athletes and performance. 5mg/kg is a common number as a pre-event dose for endurance athletes, and science seems to be mixed on ideal due to large individual variation in tolerance, response, and metabolics[1]. There are many 'thermogenic' fat loss supplements that have 150mg+ per dose taken multiple times a day.

Cyclists I know commonly take 400mg before a race to training session, and often top up over the course of the event if it's more than a couple hours. So I don't think the numbers reported are high, unless casual coffee is your basis comparison. But in the context of caffeine for fat loss, where supplements have high amounts, the numbers seem in line with common use.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752738/

replies(3): >>26612615 #>>26612960 #>>26618605 #
33. bluedino ◴[] No.26612569[source]
240mg is pretty common for the canned energy drinks
34. cseleborg ◴[] No.26612574{4}[source]
Thank you! Though anecdotal, it is super helpful to learn about your experience like this.
replies(1): >>26612872 #
35. carbocation ◴[] No.26612587[source]
Extrapolating from your comment, I guess we'd kind of want a blocked design that is placebo-vs-caffeine and exercise-vs-none.

That would tell us whether there is just an additive effect of high-dose caffeine and exercise, or if somehow the caffeine is interactive with exercise (i.e., has a bigger effect in the exercise group than in the rest group).

36. sjg007 ◴[] No.26612594{3}[source]
Poor sleep is associated with weight gain.
replies(2): >>26612608 #>>26612787 #
37. sinsterizme ◴[] No.26612607[source]
A tall (smallest size) pyke roast from Starbucks is 235 mg of caffeine. A venti (what I normally get) is 410 mg.
replies(1): >>26612627 #
38. umanwizard ◴[] No.26612608{4}[source]
I wonder if that’s because sleepiness is associated with poor impulse control. I know when I’m super tired I tend to eat whatever I want the next day.
replies(5): >>26612703 #>>26612711 #>>26612804 #>>26612921 #>>26613226 #
39. dijit ◴[] No.26612610{3}[source]
> I am pretty sure that not sleeping at all also increases fat burning as body uses less energy when asleep

From the admittedly little I know about biology and sleep science; I thought it was universally accepted that poor sleep harms your metabolism and thus would make fat-burning less likely.

replies(2): >>26612744 #>>26613462 #
40. kevinyun ◴[] No.26612611[source]
I appreciate this on the S1 filing threads where you can get some deep anecdotal insights on companies that you would have otherwise never been able to find through research.
41. PragmaticPulp ◴[] No.26612615{3}[source]
The subjects were caffeine-naive non-athletes. They had zero caffeine tolerance.

500mg is a huge amount for a caffeine-naive person, no matter how you look at it. No one goes from drinking zero caffeine to 6 Red Bulls per day without experiencing abnormally high stimulation.

replies(2): >>26612664 #>>26617486 #
42. umanwizard ◴[] No.26612622{4}[source]
It’s probably important in either case.
replies(1): >>26612816 #
43. dragonwriter ◴[] No.26612627{3}[source]
The smallest size at Starbucks is “short”, it's just not listed on the menu.
replies(1): >>26612771 #
44. Godel_unicode ◴[] No.26612655[source]
A grande (16oz) drip coffee from starbucks is over 300mg of caffeine. The problem with Red Bull is the sugar.
replies(1): >>26613058 #
45. SkyMarshal ◴[] No.26612657{3}[source]
Back in the late 00’s I discovered Redbull really helped me overcome after-lunch food-coma. I’d drink one right after lunch to help me get back to work and focus for the rest of the day.

After about 6 months of this, one day I was sitting at my desk having just finished my afternoon Redbull, and felt my heart skip a beat, literally. Like a little mini-heart attack. Scared the shit out of me, and I quit Redbull cold turkey that day.

At the time I was really into cycling, riding about 100 miles per week (50 on the weekend plus daily bike commute). I was in tip-top shape, with no family history of heart problems, and an otherwise normal, low-sugar, whole food diet.

Never experienced that since, and I wouldn’t be surprised if there are studies that find a link between super-high caffeine energy drinks and heart or other health problems.

replies(1): >>26612695 #
46. dbsmith83 ◴[] No.26612662[source]
This from the study was very interesting to me:

> In athletes, it is known that endurance performance is poorer early in the morning and late at night compared with the afternoon [6], and that MFO and Fatmax are higher in the afternoon compared to the morning whether in non-athlete male students [7], in untrained normal-weight and obese individuals [8], or in endurance-trained athletes [9]. The difference has been explained by the higher body temperature, the enhanced neural activation and contractile properties of the skeletal muscle, and the higher plasma catecholamine concentrations found in response to exercise in the afternoon compared to the morning and evening [10, 11].

So it seems like regardless of if you had caffeine or not, it is better to work out in the afternoon vs. in the morning

47. BurningFrog ◴[] No.26612664{4}[source]
I'm not sure you two are disagreeing?
48. stefanmichael ◴[] No.26612694[source]
If you ever want a very real anxiety attack drink half of a redline without any caffeine tolerance. If you want to die, drink an entire redline.

I tried it once in college and it blew my mind that something like that was available off the shelf.

replies(1): >>26613538 #
49. dbsmith83 ◴[] No.26612695{4}[source]
Ah, this is called an ectopic heart-beat (usually harmless). Back when I drank too much coffee and didn't sleep in my last year of college, I got a few of these. Now I'm a one-cup-a-day kind of guy, and it hasn't happened much anymore.
50. luxuryballs ◴[] No.26612703{5}[source]
That and you may be having an extra meal whereas you otherwise would have been asleep.
51. SkyMarshal ◴[] No.26612707[source]
Same. Also, even studies without obvious flaws need to be reproduced with same results multiple times before we can start accepting the conclusion. A single study is at best suggestive.
52. toyg ◴[] No.26612711{5}[source]
There is that and there is the “enforced fasting interval” that sleep is.
replies(1): >>26613557 #
53. notsuoh ◴[] No.26612732[source]
I'm objectively very high performing at aerobic exercise, since high school and have kept it up. I have seen quantitatively higher performance when taking 3-5 mg/kg of caffeine before exercise and regularly during. This includes anything high intensity aerobic, from swimming to running to cycling.

This is the best collection of research I have seen on the topic and where I arrived at my 3-5 number above many years ago, perhaps it will be useful and seems to speak to the broader topic at hand: https://fellrnr.com/wiki/Caffeine

54. lmilcin ◴[] No.26612744{4}[source]
No, it is not "universally accepted".

It is actually opposite. Most organisms under stress increase their energy consumption.

A good proxy for energy consumption by your body is your heart rate. Heart rate is linked to the amount of blood distributed through your body and amount of blood is amount of oxygen that is needed by your cells for metabolism.

And amount of oxygen used by cells is almost equal to the amount of energy produced (excluding those rare anaerobic regimes).

Heart rate is always lowest at night during sleep.

What you probably meant is that a person who has poor sleep will have a statistical tendency to eat more, for many reasons. One it is more difficult to exercise willpower when you are not rested well. It might also be more difficult to accurately judge whether what you feel is hunger.

To accurately compare energy use by body you would have to externally limit amount of calories ingested to same level and figure out how much CO2 you emit or how much weight you lost.

Otherwise you are measuring your regulating machine -- ie. your brain, hormones, etc. and that is whole other set of problems.

Eating makes us feel better and if you are on poor sleep you might eat just to offset it.

replies(1): >>26612943 #
55. noobrunner ◴[] No.26612771{4}[source]
Haha, I just learned this recently. It's on the menu in their app. I always order short now when I am in a mood for "unhealthy" drink
56. nullify88 ◴[] No.26612774{3}[source]
Blood thinners reduce blood viscosity increasing flow. Aspirin is commonly used together with ephedrine and caffeine to form an ECA stack. https://en.m.wikipedia.org/wiki/ECA_stack
replies(1): >>26613289 #
57. lmilcin ◴[] No.26612787{4}[source]
See my other response to sibling comment.

TLDR: weight gain is not from body using less energy but from your regulating machine being put out of balance.

Body on caffeine will still use more calories, but your brain on poor sleep will make worse choices and you will eat more just to offset unhappiness.

58. chiefalchemist ◴[] No.26612791[source]
Perhaps. But in this case, 15 ppl is not a "study". Furthermore, this had no control group.

This is not the type of information we come to HN for.

59. readme ◴[] No.26612804{5}[source]
it's because sleep regulates the hormones that control your appetite

if you mean poor control of your body's natural drive to eat which is imperative to our survival, then sure

very few people can consistently control this "impulse" -- the best way to control it is to get adequate sleep and regulate your hormones

60. ApolloFortyNine ◴[] No.26612813[source]
It's odd they didn't speak of caffeine itself as a supplement, and instead mentioned coffee.

Caffeine is a pretty common ingredient in any pre-workout, and you can get 200mg pills online cheaply.

replies(2): >>26613044 #>>26616249 #
61. watwut ◴[] No.26612816{5}[source]
Yes, especially if you have passive lifestyle. But it is not all that much how many calories you burn, but about what it does to your body in general.
62. mrfusion ◴[] No.26612828[source]
Follow up question. Does intense exercise metabolize caffeine faster?

I usually can’t sleep if I have caffeine after 2pm but if I drink it in the evening but before a big workout I don’t notice any trouble sleeping.

63. SkyPuncher ◴[] No.26612829{3}[source]
Most energy drinks include other energy additives, which I think is where the dangers come from.

I can no longer drink red bull because it gives me really bad heart palpitations. Meanwhile, I can pretty much drink coffee all day without issue.

replies(1): >>26612929 #
64. mean_gene_1976 ◴[] No.26612834[source]
Is this really a eureka moment? I mean this has been pretty obvious.
65. klyrs ◴[] No.26612845[source]
The only reason I've found to avoid it is that 1 time in 10, coffee before a long ride means that I'll urgently need to pee every few miles -- way more often than I can find a legal place to do so.
replies(1): >>26612962 #
66. krtkush ◴[] No.26612846{3}[source]
I was diagnosed with high BP very early in my life (23-24 yo). The doctor said it is okay to have everything in moderation but asked me to not touch energy drinks.
67. jniedrauer ◴[] No.26612862[source]
We've known that caffeine increases aerobic capacity for half a century now. I don't see what new information this study is bringing to the table. If you take caffeine and your aerobic capacity increases, then you will either do more work, or perform at a lower percentage of your lactate threshold. In both cases, you metabolize more fat.
68. watwut ◴[] No.26612872{5}[source]
For whatever is worth, I had similar experience. The thing, calories deficit means you are passive, tired, irritable, have problem to focus. So you are less effective at work too. How bad the irritability is for others I understood only when someone else was dieting and turned into someone constantly angry.

In addition, if you diet only, it is very easy to cause yourself annemia or other health issue. It happened to me and it actually affects life a lot. Most of sources talk about what you should not eat, but very little about how to recognize you are missing something or overdoing it.

69. jniedrauer ◴[] No.26612881[source]
Anecdotal, but I find the exact opposite to be the case. The more alert and "strong" I feel during intense training, the less likely I am to let my form slip. When you're dog tired and slouching over, that's when the injuries happen.
70. noobrunner ◴[] No.26612887{4}[source]
I agree. Whenever I decide to lose weight, I've always found that turning both the knobs(diet & exercise) at the same time in the beginning is overwhelming and doesn't work for me. I have to get into a routine for one of the two first before focussing my attention on the other. Usually, it's exercise first. Wonder if other people have same exeperience
71. DoreenMichele ◴[] No.26612921{5}[source]
One means to keep functioning while sleep deprived is to eat more. I don't think it's really poor impulse control per se. It's a coping mechanism, sort of like the body shunting waste gas through the kidneys at high altitude because you can't offload them all via breathing out and they have to go somewhere, but that's not really the optimal way to do that and it has knock on effects because urinating to remove them also drags salt and other stuff with it, thus the need to drink more and get more electrolytes at altitude. (Edit: implicitly, weight gain us the equivalent knock on effect for eating more while sleep deprived.)
72. fabatka ◴[] No.26612924[source]
... in mice.
73. retrac ◴[] No.26612929{4}[source]
Caffeine, at least in large doses, is somewhat stressful on the heart by itself. It increases respiration and blood pressure and heart rate. A strong cup of coffee can give me minor palpitations.
74. valleyjo ◴[] No.26612942[source]
>15 men participated in the study

This is no where near the number of participants that would be needed to make such a broad claim

replies(3): >>26613049 #>>26613176 #>>26613551 #
75. dijit ◴[] No.26612943{5}[source]
I’m quite sure you’re mistaken as studied animals (usually rodents) do not behave the same as humans; and ultimately if our metabolic system becomes unbalanced then our body is suffering and will certainly attempt to overcompensate or risk damaging itself.

It matters very little if we burn fat faster, though I doubt it; it matters what the outcome is. In this case it does appear that people get fatter.

> More than two dozen epidemiological studies from around the globe looking at sleep deprivation and BMI in humans have shown association between decreased obesity and an increase in sleep duration.

> Data regarding impact of sleep deprivation on weight loss is conflicting in animals and humans. Sleep deprivation in rodent models causes weight loss despite hyperphagia [63–68]. These differences in rodents and humans may be explained by increased brown fat in rodents (rarely present in adult humans), which is metabolically more active and has been shown to increase thermogenesis and total energy expenditure [67]. In conclusion, epidemiological data is suggestive of weight gain with sleep deprivation though a few studies have also noted weight gain with prolonged sleep. Based on data on sleep duration and weight, sleep hygiene counseling could form an important tool in management of obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929498/

replies(2): >>26613196 #>>26613282 #
76. SkyPuncher ◴[] No.26612951[source]
From the study:

> This began with the same warm-up protocol, followed by increments of 50 W every minute until self-reported exhaustion

Am I wrong to think that this is simply "caffeine gives you energy to push yourself harder"? They controlled calorie intake, so simple CICO would suggest a longer exercise period needs to dig into fat reserves.

Based on my personal anecdote, drinking caffeine before athletic activities gives me the energy to more consistently work at the edge of my physical limits. When I'm sleepy, I just don't care to push myself as hard.

replies(2): >>26613111 #>>26613200 #
77. hombre_fatal ◴[] No.26612954[source]
Almost seems like you're trying to sensationalize it by changing it to Red Bull, something that's actually pretty low in caffeine once you put marketing aside.

How about comparing it to Starbucks' regular hot coffee sizes?

- Short - 180 mg

- Tall - 260 mg

- Grande - 330 mg

- Venti - 415 mg

Is drinking a 12oz Tall at Starbucks really dropping your jaw?

replies(6): >>26612981 #>>26613004 #>>26613016 #>>26613097 #>>26613156 #>>26613174 #
78. SkyPuncher ◴[] No.26612960{3}[source]
> Seems like a lot when put in terms of Redbull,

Redbull doesn't actually have that much caffeine. A typically, 8oz cup of coffee has more caffeine than a redbull.

In fact, most "energy drinks" don't have that much caffeine. They have other ingredients that also provide energy.

replies(1): >>26612995 #
79. noobrunner ◴[] No.26612962{3}[source]
haha, this has happened to me during a half marathon. It cost me 10-15 mins as there was a big line outside the toilet
80. pdimitar ◴[] No.26612967[source]
If I drink a full cup of good coffee before exercise I'll likely die of heart attack. My heart is starting to literally ache after I get 3 normal gulps of coffee and wait for 15 minutes.

Other anti-oxidizing drinks like green tea do help a lot though.

It really depends on the person. I was a former coffee addict and even though I mostly have quit coffee for full 10 years now I still can't get back to regularly consuming it. It's either half a cup once two weeks or a very shitty 2-3 days after.

replies(3): >>26613246 #>>26613362 #>>26614915 #
81. have_faith ◴[] No.26612981{3}[source]
It drops my jaw that anyone drinks that regularly.
replies(1): >>26613168 #
82. schappim ◴[] No.26612995{4}[source]
In the industry the other ingredients are called “pixie dust”.

The heavy lifting is done by the caffeine.

replies(1): >>26614829 #
83. coderintherye ◴[] No.26613004{3}[source]
That's a fair point, Starbucks coffee has more caffeine than an average cup of coffee. I'm sure many people (including myself) are not aware of that.

https://www.washingtonpost.com/opinions/five-myths-about-caf...

replies(1): >>26613095 #
84. bloaf ◴[] No.26613014{4}[source]
My personal experience is that establishing a good exercise routine helps with the diet a lot. If you're pushing yourself fitness-wise, you start to notice the impact diet (and sleep) has on your performance and select for foods that won't make you miserable during your workout.
replies(1): >>26613116 #
85. scrozart ◴[] No.26613016{3}[source]
Thanks for digging these up. I agree OP would have to try to avoid first looking at coffee.
86. pengaru ◴[] No.26613021[source]
This past year I've been doing a lot of heavy manual labor; excavating large areas using a pick axe and shovel, hauling it away in a wheel barrow. And moving large ~200lb granite boulders in a wheel barrow ~1/3rd a mile up a slight grade from a nearby mountain.

At the same time I started drinking a strong pot of Earl Gray tea every morning to try get my butt in gear and outside in the dirt quicker. Normally I'm not a caffeine user. For the first week of this, my teeth would chatter and hands shake after finishing the pot of tea, it was very reminiscent of a cocaine bump. And it certainly worked well for motivating me to get busy.

But something I learned was my endurance went to shit on the caffeine. I was super impatient and wanting to do everything as fast as possible, while doing fundamentally slow long-haul heavy-mode operations. It turned out I got less done with the caffeine than without. I'd quickly burn myself out inadvertently trying to move everything faster than they were ever going to move with just my manpower. It was like the stimulant tricked me into operating deep in the realm of diminishing returns where I'm putting in 200% effort for 10% faster movement, while making myself frustrated with how long it's taking.

Now I don't think caffeine is particularly useful for anything physical that doesn't resemble a sprint, at least not for me. The psychological effects just increase the likelihood of burnout by mistreating an endurance task as a sprint.

87. retrac ◴[] No.26613029[source]
Amphetamine and methamphetamine are actually approved as treatments for morbid obesity by the FDA in America. AMP is actually still used in some cases today, though much more sparingly than historically. The side-effects and potential dependency make their use often very problematic. Still, between increasing the base metabolic rate and energy levels, and suppressing appetite, they do work.

While caffeine has a very different mechanism of action, it does appear to indirectly work on the same dopamine-adenosine system. So it's not too surprising it'd work much the same way for weight loss. And fortunately caffeine seems to be mostly self-limiting in its compulsiveness.

88. thinkingemote ◴[] No.26613044{3}[source]
Not that odd if you consider science writing should appeal to as many as possible. The study itself used these workout pills you mention which were made from green coffee beans:

https://jissn.biomedcentral.com/articles/10.1186/s12970-020-...

89. waynecochran ◴[] No.26613049[source]
As soon as a saw N = 15 then I realized this is pathetic empirical evidence. How does this even get published?
replies(1): >>26613230 #
90. thinkingemote ◴[] No.26613058{3}[source]
How about sugar free energy drinks?
replies(1): >>26613256 #
91. arcticbull ◴[] No.26613095{4}[source]
The amount of caffeine in a coffee depends on its extraction method, the grind, and to a lesser extent on roast. An espresso actually has much less caffeine than a cup of drip (60mg vs 200mg). Generally the longer you leave the beans exposed to water the more caffeine comes out, up to about 400 minutes when making cold brew. [1]

I doubt Starbucks is deviously out to over-caffeinate its customers (although if they were, they've got my vote!) but rather the difference is attributable to variations in their brewing process.

There's a limit to the amount of caffeine that can possibly come out of a bean, and so I would say that unless there's evidence they're spiking the brew, that Starbucks coffee is roughly the definition of an "average cup of coffee"

A Venti is 590mL and 415mg of caffeine, 700mg/L of coffee. Based on the chart in [1] that would be roughly speaking the midpoint of roast kind at the 150 minute mark making cold brew, 10g/100mL of coffee beans (Figure 1). Or approximately a dark roast, coarse grind hot brew (Figure 3).

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740146/

replies(4): >>26613163 #>>26613234 #>>26614489 #>>26621906 #
92. JUNGLEISMASSIVE ◴[] No.26613097{3}[source]
Coffee is a lot more than caffeine, though. It contains a whole family of monoamine oxidase inhibitors, which have a host of effects on the nervous system.

That said, Red Bull very likely contains several types of flavonoids that also act as MAO-B inhibitors.

Coffee, on the other hand, contains both MAO-A and MAO-B inhibitors mainly from the Harmala alkaloid family. Some of the compounds are neurotoxic.

replies(1): >>26613141 #
93. randlet ◴[] No.26613109{5}[source]
Same! Periods of low exercise correlate with lower moods for me and lower moods mean less will power which makes keeping my diet in check tougher. The opposite is also true.
94. thinkingemote ◴[] No.26613111[source]
I suppose you would need to ask, scientifically, what do you mean by "give you energy". Do you mean purely a kind of psychological energy, a will, motivation?
95. dbsmith83 ◴[] No.26613116{5}[source]
Yeah, working out regularly makes me think twice about ever drinking enough to get even a minor hangover. Plus, a good exercise routine inspires a good diet because after all that time and energy working out, who wants to mess it up?
96. pizza ◴[] No.26613123[source]
Wait a little longer and you'll almost surely get comments pointing out why the top comments are bad as well lol :)
97. arcticbull ◴[] No.26613141{4}[source]
It seems like caffeine alone is an MAOI [1] and that decaf may not have the same effect [2] - very cool, thank you for sharing! I know there's a lot more in coffee too, so I'm looking forward to learning more.

[edit] Found this [3] which I assume is what you were talking about? Which I assume is the reason studies show it can act as an antidepressant [4]. Fascinating!

[1] https://pubmed.ncbi.nlm.nih.gov/23850513/

[2] https://www.jwatch.org/fw108796/2014/05/06/severe-hypertensi...

[3] https://pubmed.ncbi.nlm.nih.gov/16139309/

[4] https://www.medicalnewstoday.com/articles/313988#possible-ri...

98. seaman1921 ◴[] No.26613156{3}[source]
Yes drinking two 12oz Talls at Starbucks every day is not good for your sleep.

Nespresso capsules have 60g for reference.

replies(3): >>26613540 #>>26613856 #>>26732953 #
99. fc373745 ◴[] No.26613162[source]
Alright, caffiene = vasoconstriction and exercise means high bpm.

Wouldn't this be a recipe for cardiac arrest?

100. leetrout ◴[] No.26613163{5}[source]
I get so tired of people equating espresso with high amounts of caffeine. I don't know where that originated... maybe because of the high temp / pressure extraction and the oils making it so much richer?
replies(2): >>26613343 #>>26613354 #
101. arcticbull ◴[] No.26613168{4}[source]
Well, this massive million drinker meta-analysis of coffee consumption (high levels, 5 cups a day) shows it significantly improves cardiovascular health. [1]

> A nonlinear association between coffee consumption and CVD risk was observed in this meta-analysis. Moderate coffee consumption was inversely significantly associated with CVD risk, with the lowest CVD risk at 3 to 5 cups per day, and heavy coffee consumption was not associated with elevated CVD risk.

[1] https://www.ahajournals.org/doi/full/10.1161/circulationaha....

replies(2): >>26614087 #>>26615312 #
102. wk_end ◴[] No.26613173[source]
GNCs and other health food stores sell lots of snake oil. I wouldn't be surprised if lots of the stuff on the shelves, or stuff in the stuff on the shelves, does very little, if anything, for fat burning/muscle building.
103. PragmaticPulp ◴[] No.26613174{3}[source]
> Is drinking a 12oz Tall at Starbucks really dropping your jaw?

Yes, absolutely. But I rarely consume caffeine so my experience is very different than yours.

The study used caffeine-naive individuals. That is, people without any caffeine experience or tolerance.

If you give two tall Starbucks coffees to a caffeine naive person, it will definitely cause some notable effects.

Frequent coffee drinkers tend to underestimate the impact of their caffeine tolerance. A seasoned coffee drinker consuming two of the strongest coffees on the market day after day is a different story than caffeine-naive individuals skipping straight to excessive doses of caffeine without any tolerance.

replies(1): >>26614807 #
104. benmaraschino ◴[] No.26613176[source]
Counterpoint: the investigators used a crossover design, where each participant acts as their own control. Since within-subject variation <<< between-subject variation, this makes the effective sample size much, much higher than it would seem at first. In terms of efficiency, their design’s potentially equivalent to a vanilla parallel-arm trial with close to 100 subjects (or more) in each arm. So, you definitely can obtain solid evidence from N=15 (or less), if your study is carefully designed.

Sample size is only a very small part of the overall methodological picture—design matters too.

105. satellite2 ◴[] No.26613196{6}[source]
I don't see how this contradicts GP points.

The first point is that lack of sleep is associated with increased metabolism (increased energy expenditure at rest).

The second point is that the apparent link between weight gain and sleep deprivation could be explained by involontary caloric intake increase.

106. dbsmith83 ◴[] No.26613200[source]
There's many things at play with caffeine. You have increased heart rate and bp, increased concentration/focus, appetite suppression, etc.. I don't think you can point to one effect and say 'this is the one that makes the difference' in a cause and effect kind of way. They are all too related. I personally don't think it matters in this study. You would need another study to pinpoint factors down even more I suppose.
107. sjg007 ◴[] No.26613226{5}[source]
The sleep deprived body directs calories to fat storage.
108. seaman1921 ◴[] No.26613230{3}[source]
well as long as you have a heading..

Experiments have been conducted this way since forever - just 3 days ago I was reading richard feynman's book where he talks about this issue as well - basically the people who try to run experiment properly take longer and are pushed away and never get published or cited, whereas the poorly conducted experiments which show results aligned with what would make headlines get all the attention.

This is why I take any studies, experiments, trials results with a big grain of salt.

109. SkyPuncher ◴[] No.26613234{5}[source]
A "cup" of coffee is officially 8oz and typically between 80 and 100mg.

Starbucks coffee doesn't really have a higher ratio of caffeine, just more volume than the official measurements.

That being said, I don't know anybody that drink 8oz cups of coffee.

replies(3): >>26613408 #>>26614469 #>>26615275 #
110. Felger ◴[] No.26613246[source]
Did you have to stop coffee because of those heart like symptoms ?
replies(1): >>26613368 #
111. bserge ◴[] No.26613256{4}[source]
Just use caffeine pills.
112. bserge ◴[] No.26613275[source]
And no amount of exercising will ever be better than just... eating less. The only surefire way to lose weight fast. People hate this one simple trick.
replies(3): >>26613941 #>>26615113 #>>26616262 #
113. matwood ◴[] No.26613282{6}[source]
You left out the next part of your first quote:

> More than two dozen epidemiological studies from around the globe looking at sleep deprivation and BMI in humans have shown association between decreased obesity and an increase in sleep duration. These studies however do not establish a causal relationship.

The paper also mentions and agrees with who you were responding to:

> In summary, energy expenditure is reduced during sleep. Sleep deprivation appears to increase energy expenditure.

And finally in the conclusion:

> Paradoxically a similar U-shaped relation is also noted in several studies looking at the relationship between sleep and weight, with both short and long sleep leading to weight gain.

I may have missed it, but it doesn't appear a causal relationship was ever formed between metabolic dysregluation from sleep issues and weight gain. And since both less and more sleep were associated with weight gain, is sleep or the lack thereof just another symptom of stress and depression? Both of which often cause people to eat more.

114. bserge ◴[] No.26613289{4}[source]
Can't buy ephedrine anymore. Or pseudoephedrine, which was shit anyway. They've been replaced with synephrine and other stuff, which is just bad.
replies(2): >>26613931 #>>26616322 #
115. bserge ◴[] No.26613326[source]
It's not. Just eat less of whatever you're eating.
116. Godel_unicode ◴[] No.26613343{6}[source]
Well it is much higher caffeine/volume, it's just that you (typically) drink a much lower volume of it.
117. dfee ◴[] No.26613354{6}[source]
A Starbucks Espresso shot has 75mg at 1oz.

A Starbucks dark roast (short size) has 130mg at 8oz - that is 16.25mg/oz.

That means the espresso has 4.6x the caffeine per volume. I’d say those people you’re tired of have something worth listening to.

https://globalassets.starbucks.com/assets/94fbcc2ab1e2435985...

replies(1): >>26614011 #
118. bserge ◴[] No.26613362[source]
Interesting. I had a similar experience, but recently I started taking levothyroxine and now coffee works exactly as it did 10-15 years ago.

You should check your thyroid gland/thyroxine/TSH level sometime.

replies(1): >>26613382 #
119. pdimitar ◴[] No.26613368{3}[source]
I have never seen a doctor about it. By the time I stopped coffee I already had some slight arrhythmia so I was quite scared and never pursued any more detailed info.

But yes, I stopped and got better almost instantly.

replies(1): >>26614052 #
120. pdimitar ◴[] No.26613382{3}[source]
Yep, one of my 5 thyroid hormones is having high values so I am definitely going to the doctors soon.

Whether I am epically stupid for not having done it 10 years ago is... entirely another matter.

121. bosswipe ◴[] No.26613385[source]
mg/kg is a really weird unit to use without saying how many kg were consumed.
replies(2): >>26613436 #>>26613485 #
122. bserge ◴[] No.26613387{4}[source]
Sure, but if you exercise and don't control your diet, you'll end up still fat but with more muscle underneath. Which isn't exactly the goal.
123. beforeolives ◴[] No.26613408{6}[source]
I think the point is that there is a difference between a cup of filter coffee and an espresso drink (Americano, latte, cappuccino etc) with the same volume. The first one is well... coffee, the latter contains only a shot or two of espresso and the rest of the volume in the cup is hot water/milk.
124. JeremyNT ◴[] No.26613418[source]
Regardless of this study's merits this makes some intuitive sense, since caffeine is a stimulant and a moderately performance enhancing drug. In my marathon training I consume caffeinated food as a quick "pick me up" after the first 90 minutes or so of exertion.

If you are able to run faster... well guess what... you'll also consume more calories!

125. carbocation ◴[] No.26613436{3}[source]
It's usually a unit of mg consumed per kg of body weight. (Hopefully 0 kg of which are being consumed.)
126. arcticbull ◴[] No.26613462{4}[source]
A lack of sleep leads to higher levels of cortisol and insulin, and decreases insulin sensitivity. This in turn physically prevents you from burning stored fat and leads to blood sugar being converted into fat for longer-term storage.

[1] https://www.sleepfoundation.org/physical-health/sleep-and-bl...

127. detaro ◴[] No.26613485{3}[source]
When used in contexts like this, it's mg of substance per kilogram of body weight. (with the assumption that the effect on metabolism etc somewhat scales with body weight, at least for people that are otherwise similar)
replies(1): >>26613525 #
128. bosswipe ◴[] No.26613525{4}[source]
Oh. Thank you that makes more sense.
129. matwood ◴[] No.26613538{3}[source]
I came here to write this same comment, and I have a caffeine tolerance. Redline is the pot candy bar of caffeine. It's a tiny bottle and if you don't read the side that says drink 1/2 or less too start, you can end up in a pretty bad state.

But it's still nothing compared to Ripped Fuel in the 90s. In college I could take a couple of those, lift hard for 2 hours, shower and then party all night like it was no big deal.

https://www.livestrong.com/article/32157-ripped-fuel-work/

> Thermogenic dietary supplements, more commonly known as weight-loss supplements, were classically made up of ephedrine, caffeine and aspirin, known as the ECA stack (ephedrine, caffeine and aspirin).

130. sokoloff ◴[] No.26613540{4}[source]
Do you mean mg rather than g?
131. ◴[] No.26613551[source]
132. moron4hire ◴[] No.26613557{6}[source]
The first meal after sleeping through the night is called "break-fast", after all.
133. halfmatthalfcat ◴[] No.26613856{4}[source]
Source? I drink a fair amount of coffee every morning (not any after 10am) and never had any sleep issues. The half life for caffeine is somewhere around 6 hours, no?
replies(4): >>26614070 #>>26614369 #>>26616312 #>>26623511 #
134. erickhill ◴[] No.26613894[source]
If they truly had no caffeine tolerance, iirc back when I first started ingesting more than I was used to it would make me a bit sick to my stomach.
135. dhimes ◴[] No.26613913[source]
I no longer give much attention to nutrition or sports performance studies that test a handful of people for a few weeks. It's simply not enough people, not a long enough study, and probably not controlled enough. My guess is that there are or will be (a) study(ies) with pretty much the opposite outcome.

Years ago "studies showed" that caffeine had an anabolic effect that aided muscle growth. Now it seems that the opposite is "thought" to be true. [https://pubmed.ncbi.nlm.nih.gov/28177708/]

replies(1): >>26614511 #
136. cheezerman ◴[] No.26613931{5}[source]
Ephedrine is still available over the counter, in the US, at least.
137. halfmatthalfcat ◴[] No.26613941{3}[source]
Don’t even need to particularly eat less. Calories in/calories out. As long as you’re in a caloric deficit, you will lose weight. Now what your body is actually burning to lose that weight is a different story.
replies(1): >>26616290 #
138. leetrout ◴[] No.26614011{7}[source]
But look who I was responding to: people think a single shot of espresso had more caffeine than a cup of coffee and that is not true.

Starbucks drinks typically have 2 shots (such as a grande mocha) which gonna be around the same amount of caffeine as a cup of coffee

139. jmmcd ◴[] No.26614052{4}[source]
I think a doctor would recommend to see a doctor, here.
replies(1): >>26615978 #
140. nwienert ◴[] No.26614070{5}[source]
Closer to 10 or 12 for many, it has a high variance in humans.
141. nwienert ◴[] No.26614087{5}[source]
What does it do to every other disease? Doesn't say much if it looks at a single factor outcome.
replies(1): >>26614688 #
142. airhead969 ◴[] No.26614229[source]
Caffeine is performance-enhancing, raises metabolism (temporarily), and suppresses hunger.

Unfortunately, it's readily-apparent that you can never outrun your fork, so forget about "burning calories" through cardio. The goal of fitness to lose weight ought to be weightlifting to gain as much muscle mass as possible to raise one's BMR. Passive metabolism is about the only way to do it without enrolling in BUD/S. In general, gymrattery and endless treadmill running are wasted effort.

https://youtu.be/mTABw0EyIWY

replies(2): >>26614897 #>>26617402 #
143. csa ◴[] No.26614369{5}[source]
Anecdata, but one tall (actually, even one short) at 8am will typically postpone the time I fall asleep by 4 hours and will typically reduce my sleep by an equal amount (i.e., I wake up at the same time despite falling asleep later).

I’ve run some experiments on myself, and this lasts for days at a time with one tall in the morning. If I keep at it for several days, I will crash early one evening, but still only sleep for 4 hours. It’s a nightmare for someone who typically sleeps 8 hours a night — I just feel fog-brained all the time. That said, workouts are super easy.

If I had a tall in the morning and evening on a regular basis, ugh... I can’t even imagine. I did this once for extra energy during a sports tournament (we won), but I basically had to drink myself to sleep each night.

Multiple doctors have told me that caffeine sensitivity varies from person to person, but I am on the unusually sensitive side.

replies(1): >>26621509 #
144. gabrielsroka ◴[] No.26614469{6}[source]
I make coffee at home every day. I rarely go to places like Starbucks. I just measured my cup and it's 8 oz. I have one cup every morning.
145. httpsterio ◴[] No.26614489{5}[source]
there's also an approximate 30% difference in caffeine between Arabica beans and robusta beans, the latter having more caffeine.

Starbucks use Arabica, typically Italian or French espresso based drinks ha e been made with robusta or an Arabica robusta blend.

Starbucks coffee is not higher in caffeine compared to other cafés, it can actually be lower. The only sig ificant difference is portion sizes, like you mentioned.

replies(1): >>26617779 #
146. goostavos ◴[] No.26614511[source]
>probably not controlled enough

This is the most frustrating part of any exercise science related literature. There are just so many studies that have absolutely preposterous designs. There is no shortage of papers drawing sweeping generalizations while using a sample size of 10 untrained individuals, over the course of 3 weeks, and with no regulation of diet. Then there's the general meaninglessness of "volitional failure" as a measurement -- Gah! It's maddening!

147. bryanrasmussen ◴[] No.26614593[source]
it is of course good to get confirmation that taking a stimulant that is also a diuretic increases fat-burning - as I believe most people would suspect - but I don't think that confirmation is headline level good.
148. toxik ◴[] No.26614688{6}[source]
Suffice to say, if there were meaningful risks from drinking normal amounts of coffee, it would be known by now. Its main drawback is that it makes people nervous and jittery if taken in excess.
replies(1): >>26615298 #
149. hombre_fatal ◴[] No.26614807{4}[source]
Still, not too many people are drinking 6x Red Bulls at once, the scenario you brought up as an example. Meanwhile swathes of the world are pulling into Starbucks daily, many for their first time.

It's also not two 12oz coffees, it's one at 8am and another at 5pm. It just kinda seems like everything you write here is trying to cause a reaction and it feels manipulative.

You write all this just to reveal your actual point:

> If you give two tall Starbucks coffees to a caffeine naive person, it will definitely cause some notable effects.

Well, sure. We can all agree on that. And one of the notable effects is increased fat oxidation. Notice how uninteresting this observation is by itself. No need to dress it up as something more.

150. qeternity ◴[] No.26614829{5}[source]
And anyone without a shockingly low caffeine tolerance also knows that one of the main ingredients in energy drinks is marketing.

Red Bull does nothing to most people that a cup of black coffee wouldn’t do. But the placebo effect is a helluva drug.

replies(1): >>26616593 #
151. qeternity ◴[] No.26614897[source]
The additional fat loss due to increased lean muscle mass is minimal, comparatively. All of these things like “afterburn” effect (EPOC), etc are all to give people the illusion that there are easier ways to lose weight than eating less.

I’m not a keto maximalist, do whatever works for you. But most people looking to lose weight would do wonderfully on 1,250 calories per day of high protein, medium fat, with the odd day of fasting and plenty of water and coffee. Refeed every couple of weeks to keep leptin in check.

replies(1): >>26615139 #
152. poundofshrimp ◴[] No.26614906[source]
> A total of 15 men (mean age, 32) participated in the research

A sample size of 15. Seriously?

153. amelius ◴[] No.26614915[source]
> My heart is starting to literally ache after I get 3 normal gulps of coffee and wait for 15 minutes.

Are you sure it isn't heartburn? It happens to a lot of people who drink coffee (and hasn't anything to do with the heart).

https://en.wikipedia.org/wiki/Heartburn

replies(1): >>26615986 #
154. poundofshrimp ◴[] No.26614985[source]
If they approached me, I would have been a happy 16th participant.
155. raarts ◴[] No.26614999[source]
If my calculations are correct taking a strong cup of coffee (very strong actually), will burn 6 grams more fat per sustained hour of training.

And still we don't know if total energy output was the same, because coffee can be a stimulant so may drive you to work harder.

156. whereis ◴[] No.26615028[source]
caffeine, aspirin, and ephedra - while ephedra is banned, this combo has been long known for fat burning properties. it is unsuprising that strong coffee also works.
157. rubyn00bie ◴[] No.26615113{3}[source]
I 100% agree with you. I probably should have called out the "probably net benefit" is at most an extra 2-5% weight loss over an entire year with eating correctly and exercising making up 95%+ any potential weight loss.

When I lost a bunch of weight, I counted the calories of everything I ate for about a year (and still more or less do 15+ years later; calorie content of foods is generally the same). After a few weeks/months, you pretty much memorize the calories of what you're likely to eat regularly. It makes the cost benefit analysis a lot easier, "the next X I eat is 300 calories, is that 300 calories going to provide me the satisfaction the first did?" Personally, I found the answer is almost always no, and when it's not, you generally feel good about it.

158. dhimes ◴[] No.26615139{3}[source]
I agree.

From what I understand, a pound of muscle burns 6 Cals/day (that’s kCals, but in the US we just use Cals capitalized). A pound of fats burns 2-3 Cals/day. A 25 year old amateur non- drug- enhanced male can put on maybe 10 lbs of muscle in a year with a oot of hard work.

So the idea of putting on muscle to increase metabolism in order to get lean won’t pay off for most of us.

replies(2): >>26615259 #>>26616255 #
159. nodamage ◴[] No.26615156[source]
> This is not surprising to anyone who has ever walked into a GNC, or other health food store... is it even news?

I mean, these places sell a lot of "supplements" that may or may not actually do what is claimed on the label. A triple-blinded trial showing that caffeine does actually increase fat oxidation is absolutely newsworthy, IMO.

160. Fricken ◴[] No.26615258{3}[source]
Getting my diet under control is contingent on getting my appetite under control. It's mediated by my sleep levels, stress levels, how much exercise I'm getting, what types of calories I'm eating, what time I'm eating them, and my microbiome. It's so disingenuous to say "Just eat less". If it was that simple, there wouldn't be an obesity epidemic.
161. qeternity ◴[] No.26615259{4}[source]
Precisely. I'm a big lifter, who used to be pretty chunky. I did a full recomp years ago and it definitely wasn't the added muscle/increased BMR that let me cut. It was my diet.

Muscle makes you look good with clothes on. Diet makes you look good with clothes off.

162. js2 ◴[] No.26615275{6}[source]
Coffee "cups" are measured in units of 6 oz:

https://www.triplebarcoffee.com/blog/how-many-ounces-are-in-...

163. Fricken ◴[] No.26615285{5}[source]
When I'm getting regular exercise everything else just kind of falls in to place. My appetite works properly, and I move towards my healthy body weight eating whatever I feel like eating.
164. ThrowawayP ◴[] No.26615298{7}[source]
One of the other major ones is that it can aggravate stomach problems like gastritis since both coffee (even decaf) and caffeine are said to stimulate stomach acid production.
replies(1): >>26623680 #
165. jorvi ◴[] No.26615312{5}[source]
There is also a breadth of studies that show consumption is bad - I wouldn't cheer just yet.
replies(1): >>26617079 #
166. gumby ◴[] No.26615579[source]
There was not a caffeine without exercise arm. Clearly sponsored by Big Exercise.
167. deviation ◴[] No.26615713[source]
This is incredibly anecdotal, so please take it with a grain of salt- I have a personal history of hitting the gym 5 days a week for ~2 hours for roughly 5 years. I've probably taken every caffeine supplement known to man, ranging in caffeine levels from 50mg->550mg and loaded with many other supplements (beta-alanine, creatine). I've never sustained an injury that could be described as over-exertion (Luckily, I hear it is exceptionally common with long term gym-goers).

For comparison, an old friend (let's call him Dave) started hitting the gym with me and confessed after 6 months to starting his first cycle of steroids. He developed muscle much quicker than he expected, and so his expectations rose significantly. He sustained a major injury from attempting a bench-press that he was, in every sense, muscularly abled to do- but his tendons weren't. His wrist hasn't been the same since, and he can't bench press anymore.

Anyway- coming back to the original point.. I don't believe caffeine has any effect on someone's judgement for "Can I lift that, safely?". The result of hormone abuse might give a false sense of capability, though.

replies(1): >>26615975 #
168. softwaredoug ◴[] No.26615975{3}[source]
Thanks. I specifically am thinking of running. Sudden speed increases can be a source if injury (at least have been at least once for me). I associate being caffeinated with being more driven in my running to hit some speed goal.
169. pdimitar ◴[] No.26615978{5}[source]
What can I say? Life was hectic and hugely stressful. Stress and depression have the tendency to rob you of your self-preservation instincts. I finally started recouping, some 10-12 years after I started having health problems, but what can you do. Better late than never.
170. pdimitar ◴[] No.26615986{3}[source]
I really am not. You might be correct. I'll ask the doctors when I get to them.

I just get a first heart rate and shortness of breath when drinking real coffee, so indeed it might be a heartburn.

171. thesz ◴[] No.26616075[source]
[1] https://care.diabetesjournals.org/content/25/2/364

In [1], it is shown that caffeine decreases insulin sensitivity in cells. E.g., muscle cells use less insulin.

[2] https://academic.oup.com/endo/article/142/6/2702/2989741

In [2], it is shown that insulin inhibits mitochondrial oxidation of fatty acids.

These two findings support the finding in OP - if muscle cells use less insulin due to higher caffeine levels, they use more fatty acids oxidation.

172. yellowapple ◴[] No.26616191[source]
> They must have been feeling extremely energetic.

Perhaps even uncomfortably so: https://m.youtube.com/watch?v=qRuNxHqwazs

173. yellowapple ◴[] No.26616249{3}[source]
It's also relevantly the "C" in the ECA stack (ephedrine, caffeine, aspirin), which is a well-known supplement mix for bodybuilding - one specifically intended for fat burn.
174. airhead969 ◴[] No.26616255{4}[source]
Maybe.

That's not how muscle gains work. It's exponential decrease per year with steady training: 13-18 lbs the first year, 7-9 lbs the second, and so forth until about year 5.

replies(1): >>26616721 #
175. scrollaway ◴[] No.26616262{3}[source]
Eating less can change your metabolism.

What you eat can change your metabolism.

This CICO bullshit is honestly no better than middle age alchemy beliefs from people who don't realize humans are far more complex machines than a high school science fair battery but feel smart calling out newton's third law.

Your gut flora, your metabolism, your stress levels, what times you eat, your heart rate, your existing muscle mass, your sleep, vitamin levels, all those affect how much you burn actively and passively, how much you absorb from your food, what sources of energy your body decides to burn, and your energy levels as a whole.

Weight loss is fucking hard for a reason. "Just eat less to lose weight" is akin to telling someone "just use a linter to fix your code". Good idea? Maybe. It usually helps. Silver bullet? fuck no, i don't need to tell you it's way more nuanced and complicated than that.

replies(1): >>26616433 #
176. scrollaway ◴[] No.26616290{4}[source]
> As long as you’re in a caloric deficit, you will lose weight

And depending on a million different factors, you may lose a lot of energy, burn less, as you hinted to you may lose muscle mass, do damage to your gut flora, all things which after you're done losing a couple kgs will have you wondering "why the fuck am i feeling so weak all the time, and why have I stopped losing weight?"

YMMV. "Make healthier meal choices" is better advice than "eat less, CICO".

replies(1): >>26616406 #
177. senectus1 ◴[] No.26616312{5}[source]
back when i was drinking coffee (gut has changed with age... i can't drink it anymore), It never stopped me from sleeping, it just made me not want to go to sleep.

If I knew i really needed to sleep i could at any time.

178. yellowapple ◴[] No.26616322{5}[source]
> Can't buy ephedrine anymore

Sure you can. It's called "Bronkaid" and any ol' drug store sells it here in the US. Usually you need to show ID and sign a waiver (you can only buy so much of it per month, since it's an ingredient for making meth IIRC), but other than that it's OTC, no questions asked.

If popping pills ain't your thing you could also grow ephedra yourself and brew your own "Mormon tea".

179. halfmatthalfcat ◴[] No.26616406{5}[source]
"Make healthier meal choices" is also vague, esoteric and for most people, will not result in weight loss. CICO is simple, effective and for the common person, a completely acceptable way to lose weight.

Communicating healthy eating, how your metabolism works, how each body reacts different to different kinds of foods, etc is a full time job. In a country (US) where attention spans are constantly being torn in every direction, educating people on the depths of how to correctly lose weight (minimizing muscle loss, maintaining energy levels, efficiently leveraging your body's metabolism) is a losing battle. Yes, jaded and cynical but its reality.

Sure we can be optimistic and _want_ people to lose weight correctly but if you're overweight or obese, the pros of CICO VASTLY outweigh the cons you described.

180. halfmatthalfcat ◴[] No.26616433{4}[source]
You can say the exact same thing for Keto, IF or any other alternative meal planning. There are pros and cons to eating in different ways. Throwing out CICO with the bathwater is excluding potentially millions of people who don't have the time, money or opportunity to "just eat healthier".

We have to be realistic on how we communicate how to lose weight _for the masses_. Trust me, I ventured into dietetics only to be jaded at various national and multinational attempts at building watered/dumbed down meal planning advice but throughout the years I realized that you have to have simple and easy to follow guidelines (everyone can understand CICO) so that on the whole, we're getting people to lose weight.

I'm not saying CICO is the silver bullet, far from it, but it WORKS.

replies(1): >>26638999 #
181. bjourne ◴[] No.26616593{6}[source]
Are you sure about that? I drink coffee all day long and in the evenings too. Doesn't affect me much. But some of the energy drinks gets me completely hyper so that I can't sleep.
182. dhimes ◴[] No.26616721{5}[source]
I’d love to know your source on this because I have found only (1) people relating from “experience” and (2) some theoretical maximum (around 25 pounds in a year) based on the chemical processes involved.

The decreasing ability makes sense as nobody seems to put on, say, 90 pounds of muscle. Above I was referring primarily to people just starting out trying to “get in shape.”

replies(1): >>26618749 #
183. desktopninja ◴[] No.26616790[source]
Prisoners have known this for decades!
184. jebeng ◴[] No.26616995[source]
I believe it was in Montreal that there was a study attempted for something like a Human Sexuality postgrad study, that needed to collect a certain sample size of males who had never consumed internet pornography(or something to that effect), that had to be abandoned due to complete failure to find subjects who met the criteria.

I'd imagine it would be not quite as hard to find caffeine naive subjects for a caffeine study, but not by much.

replies(1): >>26647793 #
185. arcticbull ◴[] No.26617079{6}[source]
I'm fairly confident none of them were million-person multi-year meta-analysis, although I'm always happy to be proven wrong. Do you have any broad, high-confidence studies you have in mind?
186. NoPicklez ◴[] No.26617402[source]
I find this very wrong in a couple of ways. Firstly, yes you can lose weight through upping your BMR through introducing more muscle onto the body, essentially giving yourself a bigger engine.

However, as you say you cannot outrun your fork, well you also cannot outlift your fork either.

Your body burns its carbohydrate and fat stores when exercising through cardio, now if you're going to the gym and running on a treadmill for 20 minutes you're unlikely to burn much. But if you do this consistently outside multiple times a week, you will absolutely see changes provided you aren't overeating.

This idea that cardio doesn't burn calories or help you lose weight is ludacris. If this was the case, every triathlete, cyclist or runner would be overweight.

187. Balgair ◴[] No.26617486{4}[source]
As someone that quit caffeine over quarantine, I cannot even imagine slurping half a gram of pure caffeine. I probably wouldn't sleep for a few days and I'm certain my teeth would chatter my filings out. I know it's an experiment and the people were consented, but man, that seems a bit ... mean. There's no way I can see having that much caffeine nowadays and not be a total wreck.
188. rolleiflex ◴[] No.26617779{6}[source]
My understanding is that almost no one drinks 100% Robusta, since it tastes something between burnt tire, wood (not in a good way, in a 'trying to bite raw timber' kind of way) and rubber. However it's very commonly used as, in a positive interpretation, to accentuate the taste of Arabica since it produces more 'crema' on espresso, and in a negative interpretation, as an adulterant to make coffee cheaper to produce.

Here are some people writing about their experience of drinking 100% Robusta: https://old.reddit.com/r/Coffee/comments/6u2ef4/100_robusta_...

189. giardini ◴[] No.26617891[source]
This has been known for years, if not decades. I fail to see it as "news".
190. cehrlich ◴[] No.26618605{3}[source]
Yes, this is absolutely a normal amount. I'm an amateur/hobbyist marathon runner, and I usually take about 300mg pre-race in the form of coffee, and top up another 100mg in the form of a gel about once per hour. This is roughly in line with the amounts that are recommended by most race-day nutrition plans.
191. qeternity ◴[] No.26618749{6}[source]
With a sample size of n=1 (and lots of bro science online) my experience lines up with this, the so called “noob gainz”.

When I first started lifting, strength, stamina and hypertrophy all surged for the first 6 months, and plateaued. Aside from caffeine and whey, I don’t supplement with anything else but I see plenty of people that either have great genetics, or more likely dabble with anabolics in order to get the lean mass that they have.

192. mastrsushi ◴[] No.26618831[source]
If you are old and/or have a heart condition, you probably don't want to consume a lot of caffeine before working out.

Not having a heart attack is a lot healthier than fat loss, just saying.

193. say_it_as_it_is ◴[] No.26619935[source]
If the study was about covid vaccinations, would you decide not to get a shot based on what an anonymous person on HN thought? The diffusion of expert opinions here makes it hard to take seriously.
194. 6510 ◴[] No.26621509{6}[source]
It varies a lot. I can drink a pot of strong coffee before going to bed. I do this regularly, never any problem sleeping.
195. okprod ◴[] No.26621906{5}[source]
> An espresso actually has much less caffeine than a cup of drip (60mg vs 200mg).

I think espresso has more caffeine per ounce than coffee does.

196. enominezerum ◴[] No.26623345[source]
I quickly got addicted to Monster Energy drinks working at a Lowe's Hardware store across the street from a gas station; always been a caffeind. When the coffee ones came out I would do a 2 for and drink two during a break.

Anyway, at 21 I decided to use Jack3d, back when it was damn near Meth, it had DMAA in it. I didn't know this but being the 250lb 6' guy I was, slinging grills and landscaping stuff all day, I bucked up and took the "max dose" of it the first time.

Shit, I hit the gym, did extreme cardio on an elliptical for over an hour, lifted weights with some random ripped bros, and when my girlfriend came after work I stayed and ran further on the treadmill than her and her friend. Just the readouts from the elliptical and treadmill were almost 2200 calories.

Even afterwards when we went home I couldn't wait for us to shower before laying into her I still was so wired. A year later she was talking about that night...

Yea, I bet like hell someone that hasn't ever messed with stimulants can be turned sideways by them.

197. enominezerum ◴[] No.26623511{5}[source]
Source is Anecdotal. I respond very well to caffeine, though I am a bit dependant on it. My wife, nothing. I can drink a Monster and feel good.

I am 6' 240lbs, she is 4'6" and 90lbs. I can almost microdose caffeine depending on what I am doing... Sometimes it is an energy drink, sometimes cold brew undiluted, sometimes drop coffee. Shoot, at Starbucks I tend to be a "green eye" type of man and laugh when they ask if I want space for creamer.

Unless I pound back a massive amount of caffeine within 2-3 hours of bed I have no issues sleeping; then again, I have never had issues sleeping and the few times I do forget and drink caffeinated before bed, it only delays me a few hours or results in me reading a novel into the night.

198. nwienert ◴[] No.26623680{8}[source]
Sleep problems as well and migraines.
replies(1): >>26626219 #
199. arcticbull ◴[] No.26626219{9}[source]
I believe caffeine is both a treatment for, and a cause of headaches. [1] Excedrin for instance is a migraine treatment which includes Tylenol and caffeine.

[1] https://americanmigrainefoundation.org/resource-library/caff...

replies(1): >>26627678 #
200. nwienert ◴[] No.26627678{10}[source]
Reason it’s a treatment is helping absorption typically, but also, a lot of people’s headaches are from withdrawal so it helps in the way drinking a beer helps a hangover.
201. jfengel ◴[] No.26638999{5}[source]
CICO is the core of any effective diet. The rest of it is all about trying to enforce it. Which is all about keeping people from feeling hungry, bored, or otherwise failing to follow through.

Most diets work for the first few weeks because people are engaged by the novelty. Longer term compliance depends a lot on the person, both mentally and physically (including all the complexities of muscle mass, gut biome, and the whole nine yards). There's no silver bullet. You just have to keep at it until you find something that you can stick with.

What works for me is doing my own cooking, keeping a lot of vegetables around, and getting out of the house so that I'm too busy to stuff snacks into my face. I suspect that would work for a lot of people -- though that last part is really difficult with an office job.

That's me. Everybody else, good luck.

202. jonnycomputer ◴[] No.26647793{3}[source]
And if you did find them, one had to wonder how representative they are of the general population.
203. seaman1921 ◴[] No.26732953{4}[source]
To everyone replying - "i can sleep even after drinking 100 coffees" - caffeine consumption affects certain stages of your sleep even though you might fall asleep, source is the book 'why we sleep'. All stages of your sleep are important, so if you are only getting rem sleep it is not good.