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228 points curmudgeon22 | 1 comments | | HN request time: 0.203s | source
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PragmaticPulp ◴[] No.26612365[source]
> Subjects ingested 3 mg/kg of caffeine or a placebo at 8am and 5pm

3mg/kg is over 250mg of caffeine for an average weight man. Twice a day makes that 500mg.

An 8.4oz can of Red Bull contains 80mg of caffeine. They were giving these people an amount of caffeine equivalent to 6 cans of Red Bull. Not a perfect comparison because Red Bull contains other ingredients, but that's still a lot of caffeine. For another point of reference, that's 2.5 shots of 5 hour energy (200mg caffeine per bottle).

To top it off, the subjects were caffeine-naive, so they had no caffeine tolerance. They must have been feeling extremely energetic.

No wonder they burned more fat. I'm not sure this is going to translate to your casual coffee drinker or someone with a high caffeine tolerance.

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hombre_fatal ◴[] No.26612954[source]
Almost seems like you're trying to sensationalize it by changing it to Red Bull, something that's actually pretty low in caffeine once you put marketing aside.

How about comparing it to Starbucks' regular hot coffee sizes?

- Short - 180 mg

- Tall - 260 mg

- Grande - 330 mg

- Venti - 415 mg

Is drinking a 12oz Tall at Starbucks really dropping your jaw?

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JUNGLEISMASSIVE ◴[] No.26613097[source]
Coffee is a lot more than caffeine, though. It contains a whole family of monoamine oxidase inhibitors, which have a host of effects on the nervous system.

That said, Red Bull very likely contains several types of flavonoids that also act as MAO-B inhibitors.

Coffee, on the other hand, contains both MAO-A and MAO-B inhibitors mainly from the Harmala alkaloid family. Some of the compounds are neurotoxic.

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1. arcticbull ◴[] No.26613141[source]
It seems like caffeine alone is an MAOI [1] and that decaf may not have the same effect [2] - very cool, thank you for sharing! I know there's a lot more in coffee too, so I'm looking forward to learning more.

[edit] Found this [3] which I assume is what you were talking about? Which I assume is the reason studies show it can act as an antidepressant [4]. Fascinating!

[1] https://pubmed.ncbi.nlm.nih.gov/23850513/

[2] https://www.jwatch.org/fw108796/2014/05/06/severe-hypertensi...

[3] https://pubmed.ncbi.nlm.nih.gov/16139309/

[4] https://www.medicalnewstoday.com/articles/313988#possible-ri...