They're quite difficult to use without looking at them, and I've got better things to look at while driving. Better buttons that don't move and have "presence" than I can feel without looking.
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In my first car, I could operate the windows, climate control and sound system without taking my eyes off the road at all, although I had to glance briefly at the (fixed) display to see what radio station I was tuned to if it wasn’t obvious.
Old-school radios were a lot more user-friendly with preset station buttons and a tactile volume control that actually felt like it was connected to something.
Those controls are typically on some surface of the car your hand is braced on. They're also very simple physical controls with a good amount of tactile feedback. It's hard to fuck up a simple push button window control or AC dial. Even on a bumpy road you'd be hard pressed to have trouble with such controls.