Bill Atkinson's psychedelic user interface

We need to push to make this stuff legal. I wouldn't go so far as to say lets sell it OTC vape pens at gas stations but a middle ground where you can go to a doctor to have this treatment performed.

I personally have never taken DMT though from everything I've read and heard on podcasts it's not something to be taken lightly. I think having a sort of "DMT Clinic" that you can go to would be the best middle ground of allowing the public access to these substances while also ensuring that there is a trained professional there to guide you through the process.

Saying "trained professional" in this context feels wired because this stuff has been underground for so long but I think it's starting to bubble up into the mainstream enough that we need to start bringing all that "into the light". Lets have training programs that teach people how to administer this stuff properly, how to deal with the negative side effects, etc.

One of the things that while I find understandable is ridiculous is the fact that Bill had to use a pseudonym in the community. I feel like if were at the point where you have C-suite types at Apple taking this stuff, it's time to think about making it available to the broader public.

5-Meo is kind of nasty because it has a non-linear pharmacology.

the normal dose is 5-10mg, but LD50 in sheep is about 100mg, it might be as low as 30mg in humans.

It absolutely should not be legal, at least to anyone. Perhaps require training in dealing with drugs with a low therapeutic index

LD50 in sheep:

1–5 mg/kg IV

1–2 mg/kg SC

85 mg/kg O

In mice:

75–115 mg/kg IP

48 mg/kg IV

113 mg/kg SC

278 mg/kg O

They were administering over 30mg to humans in trials. (Metzner (2013); Shulgin and Shulgin (1997); Ott (2001); Davis et al. (2018); Uthaug et al. (2020a))

Sheep are susceptible to toxicity from certain tryptamine alkaloids because of their physiology.

These alkaloids, especially those that are N,N-dimethylated, can trigger neurological symptoms in sheep, such as convulsions, spasticity, and gait issues. The alkaloids are suspected to affect the brain and spinal cord by interacting with serotonin receptors.

5-MeO-DMT is an N,N-dimethylated compound. Its full chemical name is 5-methoxy-N,N-dimethyltryptamine. That indicates the presence of two methyl groups attached to the nitrogen atom of the tryptamine backbone.

Stay safe, everyone!