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372 points Eumenes | 1 comments | | HN request time: 0.603s | source
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robwwilliams ◴[] No.42201028[source]
Not a solid paper—-more like an abstract. I could not find any information on the strain or type of mice they studied. Data from one strain often fails to generalize to others. Trying to leap to human implications is beyond risky.
replies(2): >>42201086 #>>42202786 #
jr000 ◴[] No.42202786[source]
It says in the paper they used 21-week-old male C57BL/6 mice, as well as AC16 human immortalized cardiomyocytes
replies(1): >>42209724 #
1. robwwilliams ◴[] No.42209724[source]
Ah, thanks. I looked but not carefully enough!

C57BL/6 – the canonical inbred fully homozygous mouse that unfortunately is used as the “HeLa cell” of almost all experimental murine biomedical research. I understand the reason this happened, but there is no excuse in 2024 to use just one genome (and an inbred one at that) to test translational relevance.

Consider this work a pilot worth testing in NZO, DBA, A, C3H and BALB strains and some F1 hybrids. Whatever the results they should have good generality to mice in general.