←back to thread

Weight-loss drug found to shrink muscle in mice, human cells

(www.ualberta.ca)
363 points Eumenes | 2 comments | 20 Nov 24 23:53 UTC | HN request time: 0.419s | source
Show context
kbos87 ◴[21 Nov 24 02:14 UTC] No.42200375[source]▶
There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.

For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

replies(11): >>42200578 #>>42201025 #>>42201032 #>>42201081 #>>42201330 #>>42201587 #>>42201871 #>>42202077 #>>42202377 #>>42203787 #>>42211708 #
arcticbull ◴[21 Nov 24 06:08 UTC] No.42201587[source]▶
Studies show strength training while losing weight can retain almost 100% of muscle.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5946208/

replies(1): >>42202530 #
scruple ◴[21 Nov 24 09:27 UTC] No.42202530[source]▶
Anecdotally, it takes far less strength training than one would expect, too, to maintain muscle mass. From what I've experienced, 30 minutes a week, given sufficient stimulus, is enough.
replies(1): >>42203507 #
1. cthalupa ◴[21 Nov 24 12:07 UTC] No.42203507[source]▶
There are more and more PhD researchers focusing on resistance training these days, and yeah, it turns out the minimum effective dose is waaaaaay lower than we previously thought.

https://www.minimumdosetraining.com/ - free training program + links to a bunch of studies the author was involved in on this specific subject.

replies(1): >>42206800 #
2. scruple ◴[21 Nov 24 17:53 UTC] No.42206800[source]▶
I love this so much, thanks for sharing. I have my own minimum effective dose protocols that I use when life is kicking me in the face but I am going to try these on for size during the coming holiday season.