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Weight-loss drug found to shrink muscle in mice, human cells

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263 points Eumenes | 2 comments | 20 Nov 24 23:53 UTC | HN request time: 0.42s | source
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kbos87 ◴[21 Nov 24 02:14 UTC] No.42200375[source]▶
There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.

For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

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arcticbull ◴[21 Nov 24 06:08 UTC] No.42201587[source]▶
Studies show strength training while losing weight can retain almost 100% of muscle.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5946208/

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1. scruple ◴[21 Nov 24 09:27 UTC] No.42202530[source]▶
Anecdotally, it takes far less strength training than one would expect, too, to maintain muscle mass. From what I've experienced, 30 minutes a week, given sufficient stimulus, is enough.
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2. cthalupa ◴[21 Nov 24 12:07 UTC] No.42203507[source]▶
There are more and more PhD researchers focusing on resistance training these days, and yeah, it turns out the minimum effective dose is waaaaaay lower than we previously thought.

https://www.minimumdosetraining.com/ - free training program + links to a bunch of studies the author was involved in on this specific subject.