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Weight-loss drug found to shrink muscle in mice, human cells

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234 points Eumenes | 8 comments | 20 Nov 24 23:53 UTC | HN request time: 0s | source | bottom
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diath ◴[21 Nov 24 05:15 UTC] No.42201353[source]▶
The problem with appetite suppression drugs is that they simply make you not feel hungry, but do nothing to fix your lack of discipline and self-control, I'm sure most people who lose weight on these drugs, and then come off, will just go back to their bad habits.
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echoangle ◴[21 Nov 24 05:26 UTC] No.42201405[source]▶
So why not just stay on the drugs?
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1. bluSCALE4 ◴[21 Nov 24 05:33 UTC] No.42201436[source]▶
Most kill you. If I didn't misread articles on ozempic, they can cause digestive problems where food rots in your stomach. Bad depression was another side effect which blows my mind since you'd think looking better would make you feel great. And these were the minor things.
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2. cthalupa ◴[21 Nov 24 05:37 UTC] No.42201450[source]▶
> digestive problems where food rots in your stomach

I assume you mean gastroparesis - this is an extremely rare side effect

> Bad depression

Again, pretty rare side effect.

If you think these are the minor things I'm confused as to what you think the major side effects are.

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3. tokioyoyo ◴[21 Nov 24 05:42 UTC] No.42201474[source]▶
I don't think you realize the amount of people have taken Ozempic or similar drug. I'm lucky enough that I haven't had issues with body weight, but if I believe the stats (and my observations in real world confirm it), about 15% of adults are on it.

If it was "killing people", we would be seeing it literally everywhere. We're not talking about a small scale 50K+ observation... we're talking about literal millions.

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4. cyberax ◴[21 Nov 24 05:56 UTC] No.42201523[source]▶
> Bad depression was another side effect

What? Ozempic has been noted for its mild _anti_ depression activity.

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5. echoangle ◴[21 Nov 24 06:08 UTC] No.42201586[source]▶
This says 6% are currently on a GLP-1 drug and 15% have ever taken one in their life:

https://amp.cnn.com/cnn/2024/05/10/health/ozempic-glp-1-surv...

replies(1): >>42201925 #
6. adgjlsfhk1 ◴[21 Nov 24 07:00 UTC] No.42201830[source]▶
both can be true. it can reduce depression in 60% of people and increase it in 10%
7. tokioyoyo ◴[21 Nov 24 07:21 UTC] No.42201925{3}[source]▶
Fair, I remembered my stats wrong. But it's still 15M people in US that are actively on it. That's a lot of people.
8. Elinvynia ◴[21 Nov 24 08:31 UTC] No.42202270[source]▶
Gastroparesis is literally the method of action of GLP1 agonists. It slows gastric motility. Gastroparesis is literally slowed motility of the stomach (where 20% of food stays in your stomach after 4 hours). It doesn't matter why, that is the literal diagnostic criteria, ergo it literally causes gastroparesis.