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206 points pseudolus | 3 comments | | HN request time: 0.001s | source
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shswkna ◴[] No.45999858[source]
From the article:

> They can also increase suicidal ideation.

A very close family member committed suicide, after Prozac dosage adjustments made his brain chemistry go haywire.

This happened 30 years ago, and it has been known to us that Prozac can cause this, since then.

The Guardians headline is way, way understating the real situation here.

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carsoon ◴[] No.45999887[source]
The problem with suicidal depression is that if someone has created the thought pattern that death is best, then removing the symptoms of depression (lethargy, lack of energy, no willpower) now gives the person the ability to actually follow through with the act.

Medications almost always target symptoms and never address root causes.

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fragrom ◴[] No.46000022[source]
This is what my psychiatrist more or less warned me about when I went on medication; that a lot of people who are suicidal lack the energy and ability to plan their suicide, and medications can sometimes undo those particular symptoms and people manage to end themselves.

I'm not sure what kinds of studies have been done about it, but I've had a few therapists same similar ideas. If it's not a studied phenomenon, then it has folks that believe it exists.

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DANmode ◴[] No.46001309[source]
Almost like depression is an acute toxicity caused by physiological variance (or infection related) detox inefficiency!
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mapontosevenths ◴[] No.46008617[source]
What is "detox inefficiency"?

EDIT - I ask because the only results I get when searching are a Harvard article debunking it. I'd rather hear the opinion of someone that actually believes in it before I read about why it's all malarky. I believe in arguing against the best version of someones argument.

https://www.health.harvard.edu/staying-healthy/the-dubious-p...

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1. DANmode ◴[] No.46008758{3}[source]
https://my.clevelandclinic.org/health/body/glymphatic-system

PS Thanks for keeping this a good place to be!

https://news.ycombinator.com/newsguidelines.html

More for the avid reader:

1.) https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/

2.) https://pubmed.ncbi.nlm.nih.gov/40012567/

3.) https://pubmed.ncbi.nlm.nih.gov/36498538/

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2. purple_turtle ◴[] No.46008880[source]
Your first linked page has no word "depression" on it
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3. DANmode ◴[] No.46009202[source]
It wasn’t intended to.

It was just the best “every man” link I could provide for understanding how efficacy of toxin-clearing (toxicity) could be related to depression, other struggles with homeostasis.

Did you grasp the connection?