Every time I give it another chance, usually on a new install, I find the same, that a bunch of applications, sometimes conflicting, cannot be removed.
Mate was my favorite for many years, but it seems neglected now. Therefore I stick with xfce, which my primary complaint for is having an arbitrary, unmodifiable grid arrangement for desktop icons, which I find very irritating.
I think, but can't recall with certainty, network-manager (or network-dictator) is one example of an application that can't be uninstalled without taking the whole KDE with it.
Edit: at the predictable risk of being silently stoned to death as happens every time I criticize Network-Manager, which I will always despise from here to Elysium, I love wicd. Please bring it back.