I have not used 5-meo, but for n,n DMT the vape is without a doubt the most convenient method.
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It's active intranasally and well as buccally/sublingually.
Effects-wise, it feels roughly identical to DMT but with a longer duration.
I made this mistake exactly once, with 4-AcO-DMT.
That was the last time I ever did such a thing.
(If you do this, make sure you inject the upper-outer quadrant. The closer to your midline you go, the further the risk of you hitting a nerve.)
If you're very experienced and want to do it for novelty's sake, go for it; I'd warn you, but anyone considering this should know what they're likely in for.
Nearly immediately after injection, I became so filled with vibrating, psychedelic energy I thought my soul was going to be ripped from my body. I had to clutch the edge of the sink, trying not to vomit while staring at the exploding fractals swirling in the metallic reflection.
It only lasts about 2 hours. I'd not particularly rate the experience as "good".
For 5-meo I generally do 6-8mg prepared as above. That seems subjectively close to 15-20mg vaped (powder in a glass pipe not in a “juice” vape).
But either of those are definitely a commitment to the ride, lol. I do like the mixed jaguar vape cartridges for micro dosing though (like Bill prepares them in the article). Very easy to control your dosage that way with the ability to start slow and add more with additional puffs.
But 4-AcO has much less body load and no nausea from the organic matter that'd usually be sitting in your stomach, I think it's better than "organic" shrooms.
5-MeO is a lot stronger mg-for-mg, you're quite brave at those doses IMO!
Truth be told, I was more of a fan of the lighter headspace phenethylamines, like 2C-B or even 25i/25b-NBOMe.