Maybe our first AGI is just a Petri dish brain with a half-decent python API. Maybe it’s more sand-based, though.
I call this the 'Cardinality Barrier'
As far as physicists believe at the moment, there's no way to ever observe a difference below the Planck level. Energy/distance/time/whatever. They all have a lower boundary of measurability. That's not as a practical issue, it's a theoretical one. According to the best models we currently have, there's literally no way to ever observe a difference below those levels.
If a difference smaller than that is relevant to brain function, then brains have a way to observe the difference. So I'm sure the field of physics eagerly awaits your explanation. They would love to see an experiment thoroughly disagree with a current model. That's the sort of thing scientists live for.