Maybe our first AGI is just a Petri dish brain with a half-decent python API. Maybe it’s more sand-based, though.
I call this the 'Cardinality Barrier'
Infinite and “finite but very very big” seem like a meaningful distinction here.
I once wondered if digital intelligences might be possible but would require an entire planet’s precious metals and require whole stars to power. That is: the “finite but very very big” case.
But I think your idea is constrained to if we wanted a digital computer, is it not? Humans can make intelligent life by accident. Surely we could hypothetically construct our own biological computer (or borrow one…) and make it more ideal for digital interface?
Everything in our universe is countable, which naturally includes biology. A bunch of physical laws are predicated on the universe being a countable substrate.
As far as possible reasons that a computer can’t achieve AGI go, this seems like the best one (assuming computer means digital computer of course).
But in a philosophical sense, a computer obeys the same laws of physics that a brain does, and the transistors are analog devices that are being used to create a digital architecture. So whatever makes you brain have uncountable states would also make a real digital computer have uncountable states. Of course we can claim that only the digital layer on top matters, but why?
But since we don’t have a working theory of quantum gravity at such energies, the final verdict remains open.
As far as physicists believe at the moment, there's no way to ever observe a difference below the Planck level. Energy/distance/time/whatever. They all have a lower boundary of measurability. That's not as a practical issue, it's a theoretical one. According to the best models we currently have, there's literally no way to ever observe a difference below those levels.
If a difference smaller than that is relevant to brain function, then brains have a way to observe the difference. So I'm sure the field of physics eagerly awaits your explanation. They would love to see an experiment thoroughly disagree with a current model. That's the sort of thing scientists live for.
But biological brain have significantly greater state space than conventional silicon computers because they're analog. The voltage across a transistor varies approximately continuously, but we only measure a single bit from that (or occasionally 2 for nand).