←back to thread

133 points gnabgib | 1 comments | | HN request time: 0.203s | source
Show context
ggm ◴[] No.44450388[source]
In cell cultures. So nothing about topical, or digestive pathways. Just, expose cells to vitamin c rich medium.

How would topical application work, and what kind of homeostasis effect, from ingestion.

If you are low on vitamin c in your diet, sure. If not, you may not get much benefit from having more.

replies(3): >>44451394 #>>44452463 #>>44453099 #
majkinetor ◴[] No.44452463[source]
Everybody is low on C in diet. It's thermolabile, and there is glucose competition for GLUT transporters.

IMO, everybody should take at least 2g daily in a couple of doses, particularly smokers.

replies(3): >>44453579 #>>44454309 #>>44460877 #
nabla9 ◴[] No.44453579[source]
This is not true. 2g is the max recommended dose.

Most people can get enough vitamin C each day from food or drink. 3/4 cup of orange juice daily is enough. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-h...

Taking vitamin C orally decreases muscle mitochondrial biogenesis and harms the health benefits of training, like increased insulin resistance. (well established from multiple studies, easy to google).

There was huge antioxidant craze in late 90's and 00's when taking antioxidant supplements like C was considered the right thing to do. Now we know that just taking more antioxidants does not directly help with oxidization tress, because it messes up metabolism and can even increase it.

replies(2): >>44454064 #>>44454204 #
bryant ◴[] No.44454064[source]
For those who don't want to Google:

https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/jphy...

https://www.pnas.org/content/106/21/8665

replies(1): >>44454197 #
majkinetor ◴[] No.44454197[source]
Cherry picking 2 studies out of zillions and calling it science? Good job
replies(2): >>44454531 #>>44460906 #
1. jb1991 ◴[] No.44460906[source]
There are a large number of studies on this topic, in part because vitamin C supplements are so widely used and easily accessible. Several people have already shared relevant research in this thread.

Before promoting high-dose supplementation as universally safe or beneficial, I strongly recommend doing more in-depth research. It’s important to understand the potential risks especially since this kind of advice, if followed without medical oversight, can have serious health consequences.