How would topical application work, and what kind of homeostasis effect, from ingestion.
If you are low on vitamin c in your diet, sure. If not, you may not get much benefit from having more.
IMO, everybody should take at least 2g daily in a couple of doses, particularly smokers.
Find me a case report about the danger of vitamin C (not a theoretical one) and we can talk. Otherwise, you are free to behave and believe in whatever you want.
> Prolonged high supplementation doses is actually very dangerous.
Reference please.
Here is one: https://www.tandfonline.com/doi/abs/10.1080/15563650.2019.16...
It shows no deaths from vitamins. This is from 2018, but its like that every year. While it doesn't account for damage as its highly uncertain to pinpoint exactly what happened in any human, at least you know there are no deaths, while at the same time, there are deaths for any drug (aspirin for example).
> I’ve also had a family member who did permanent kidney damage by prolonged usage of supplementation.
You mean, you or your doctors suppose it was about supplementation? And what supplementation? You can damage yourself or die with anything, water included, or you come with defective organ from the day 0. All that is not relevant for others.
Bashing on supplements is in any case irresponsible and you spread fear because you are not informed, its similar to anti-vacc movement - it never happens that entire technology domain is invalid - particular instance of drug/supplement/vaccine/herb can be.
The risk to kidneys is well documented. You seem to be concentrating on whether a person dies or not, but the risk to quality of life is not to be dismissed either. There are innumerable warnings and studies about this over the years.
https://doi.org/10.1001/jamainternmed.2013.2296
https://www.sciencedirect.com/science/article/pii/S002231662...
(these are just for starters -- it's a huge area of research with many results that encourage caution)
There have also been studies shared by others here in this thread with you that you are casually dismissing as "cherry picking". It's irresponsible.