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1162 points jbredeche | 2 comments | | HN request time: 0.413s | source
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MrZander ◴[] No.43998447[source]
> To accomplish that feat, the treatment is wrapped in fatty lipid molecules to protect it from degradation in the blood on its way to the liver, where the edit will be made. Inside the lipids are instructions that command the cells to produce an enzyme that edits the gene. They also carry a molecular GPS — CRISPR — which was altered to crawl along a person’s DNA until it finds the exact DNA letter that needs to be changed.

That is one of the most incredible things I have ever read.

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poyu ◴[] No.43998602[source]
Made it sound like it's a computer, is it Turing complete?
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koeng ◴[] No.43998855[source]
It's fundamentally different than a computer and arguably more complete.

The talk of "crawling along the genome" is kinda fundamentally wrong though and is a bit irking - CRISPR kinda just bumps around until it hits a PAM site, in which case it starts checking against sgRNA. Much more random than they make it seem

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1. anthk ◴[] No.44000187[source]
This is crazier: https://www.sciencealert.com/are-we-all-quantum-computers-wi...

About CRISP, it's like the ultimate Perl+Regex for the body.

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2. dagurp ◴[] No.44003835[source]
sounds more like sed