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263 points paulpauper | 1 comments | | HN request time: 0.208s | source
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meindnoch ◴[] No.43716014[source]
Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
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Aurornis ◴[] No.43718150[source]
Similar adaptions occur in muscle. The extent of new muscle fiber development (hyperplasia) is debated, so there are multiples factors influencing how muscle retains some memory of past strength ability.

Once you’ve reached a level of physical strength it’s easier to return to that level in the future. This has been a topic of debate in the sports world because past anabolic steroid use could therefore carry benefits into the future long after the athlete has stopped using the steroid. Non-professional athletes shouldn’t get too excited about using steroids, though, because the damage steroids do to the body’s own hormone systems also has lasting effects unless you plan on doing TRT for the rest of your life, which has its own downsides.

For average people this does show the importance of getting at least some exercise when you’re young. It’s much easier to get a little bit fit when you’re young which then makes it easier to stay fit in the future. Never too late too start.

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ben7799 ◴[] No.43718213[source]
I can't remember exactly what I was listening to, maybe some kind of NPR podcast.

But the doctor was mentioning that none of the influencers influencing young people to try T and Steroids (which is rampant right now) are ever mentioning that you are on a ticking clock to infertility as soon as you start this stuff. Some people can regain their fertility but it might take years, and some people are going to be permanently infertile even staying on HRT.

Plenty of those "alpha male" guys on social media are shooting blanks.

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joncrane ◴[] No.43718768[source]
This is interesting because about 20 or so years ago when I was super into bodybuilding, you couldn't talk about a "cycle" on a bodybuilding forum without talking about a "post cycle protocol."

I know that's different than permanent TRT but I feel like you couldn't get very far researching that stuff without understanding that you natural test production (and sperm production) would get "shut down" as soon as you started adding exogenous androgens.

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Aurornis ◴[] No.43718868[source]
Yeah, it's well known that steroids shut you down. The problem with the broscience is that the PCT is talked about like it reverses everything like an antidote, but long-term bodybuilders often end up on TRT because eventually they can't get back to baseline.
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1. gr3ml1n ◴[] No.43721169[source]
That isn't true. Dedicated bodybuilders, starting more commonly ~5 years ago, decided that PCT wasn't worth it. Instead of typical 16-20 week cycles followed by 4-6 weeks of PCT, they adjust the dose between supraphysiological and (generally) top-of-normal, i.e.: blast and cruise.

It's not because they couldn't recover, it's because they don't want to or see the point.