I wouldn't put too much stock in this. Asimov was a fantasy writer telling fictional stories about the future. He was good at it, which is why you listen and why it's enjoyable, but it's still all a fantasy.
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Did he though? Or was the Butlerian Jihad backstory whose function was allow him to believably center human characters in his stories, given sci-fi expectations of the time?
I like Herbert's work, but ultimately he (and Asimov) were producers of stories to entertain people, so entertainment always would take priority over truth (and then there's the entirely different problem of accurately predicting the future).