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Scientists uncover key mechanism in evolution: Whole-genome duplication drives

(www.sciencedaily.com)
76 points docmechanic | 11 comments | 29 Mar 25 13:39 UTC | HN request time: 1.013s | source | bottom
1. yarnover ◴[02 Apr 25 07:35 UTC] No.43554452[source]▶
It has happened in plants over and over again.
replies(3): >>43555635 #>>43557483 #>>43558758 #
2. echelon ◴[02 Apr 25 11:37 UTC] No.43555635[source]▶
Gene dose increases in plants lead to bigger vegetables and fruiting bodies. We've taken advantage of this during domestication of several species.

Gene dose increases in animals lead to total dysfunction and death in embryonic development.

replies(3): >>43555798 #>>43558155 #>>43559104 #
3. eimrine ◴[02 Apr 25 12:08 UTC] No.43555798[source]▶
Dosis sola facit venenum?
4. flobosg ◴[02 Apr 25 15:03 UTC] No.43557483[source]▶
In bacteria as well!
5. kjkjadksj ◴[02 Apr 25 16:00 UTC] No.43558155[source]▶
There are species of fish that have gone through whole genome duplication.

https://www.nature.com/articles/s41559-023-02299-z#:~:text=P...

6. kkylin ◴[02 Apr 25 16:57 UTC] No.43558758[source]▶
And in yeast there has long been evidence for WGD. See, e.g., https://pmc.ncbi.nlm.nih.gov/articles/PMC4529243/ & references therein.

Edit: I posted this without looking at the paper (which is about yeast). Doh.

7. dekhn ◴[02 Apr 25 17:28 UTC] No.43559104[source]▶
dose is such a weird term for "copies"
replies(1): >>43559445 #
8. flobosg ◴[02 Apr 25 18:02 UTC] No.43559445{3}[source]▶
It’s quite… historical.
replies(1): >>43560448 #
9. echelon ◴[02 Apr 25 19:18 UTC] No.43560448{4}[source]▶
https://en.wikipedia.org/wiki/Gene_dosage

Historical-sounding, maybe? It's still used in the literature:

https://www.nature.com/articles/s41467-022-32144-z

https://www.nature.com/articles/s41467-024-48960-4

https://pmc.ncbi.nlm.nih.gov/articles/PMC10757140/

replies(2): >>43560925 #>>43562818 #
10. dekhn ◴[02 Apr 25 20:04 UTC] No.43560925{5}[source]▶
Yeah, when I saw the original comment I tried to find the source of the term but wasn't able to find it.

To me it sounds like medical genetics terminology (known for terms like "penetrance", "allele", "epistasis", "locus") whereas I'm a molecular biologist/biophysicist, which has far more precise ways of describing the underlying physical model.

11. flobosg ◴[02 Apr 25 23:06 UTC] No.43562818{5}[source]▶
A term can be still used in literature for historical reasons. Both concepts are not mutually exclusive.