Symmetry between up and down quarks is more broken than expected

What are the consequences for this breakage? The article says current models do not easily fit the asymmetry but does not state what parts of our understanding will break if those models are wrong.

Strong interactions are notoriously difficult to calculate from the first principles. So typically it is not done, but rather theoreticians try to guess the result and use the experimental data to partially fill the calculation gaps.

So I expect in this cases the guesses were wrong and the Standard Model will manage to explain that as well.

Working like that, it sounds like the standard model can explain literally anything...