Weight-loss drug found to shrink muscle in mice, human cells

It would seem wise to potentially add a low dosed anabolic androgenic steroid like Anavar (Oxandrolone) [1] during a course of Ozempic. This would help keep skeletal muscle in tact during a calorie deficient period. A low dose wouldn't be expected to cause much, if any, side effects. But it's something that would be best put through rigorous studies.

But bodybuilders have been using tricks like these for decades (obviously at much more ridiculously high amounts) that work quite successfully for this exact purpose.

[1] https://en.wikipedia.org/wiki/Oxandrolone

I have done exactly this. I stack semaglutide with ~ 1 ml testosterone and .35 ml of anavar weekly. I’ve transitioned out of regularly competing in powerlifting to running and yoga everyday. 47lbs down in 5 months and havent felt this good since college.

Can you tell if you're retaining muscle with that combination? Is this a doctor prescribed protocol or a DIY stack?

I have had three major bouts of weightloss so I can say with some confidence im retaining muscle in my lower body (because of the return to running) but have lost a lot in my chest and back from the significant reduction in heavy lifting but the muscle definition is better. This is almost exactly what we expected to happen and yes, Im working with an actual sports focused md. Insurance costs for HRT and wegovy were through the roof.