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372 points Eumenes | 2 comments | | HN request time: 0.016s | source
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kbos87 ◴[] No.42200375[source]
There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.

For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

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1. FollowingTheDao ◴[] No.42203787[source]
I would be more concerned about the thyroid cancer when taking these drugs...

https://scholar.google.com/scholar?as_ylo=2024&q=glp+1+thyro...

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2. cthalupa ◴[] No.42204189[source]
The two meta-analysis are interesting, I think.

https://www.liebertpub.com/doi/abs/10.1089/thy.2023.0530

> Overall there is no conclusive evidence of elevated thyroid cancer risk.

https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/do...

> Our meta-analysis showed that GLP-1RA treatment could be associated with a moderate increase in relative risk for thyroid cancer in clinical trials, with a small increase in absolute risk. Studies of longer duration are required to assess the clinical implications of this finding.

It's potentially a possibility, but the absolute risk seems to still be quite low.