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Weight-loss drug found to shrink muscle in mice, human cells

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363 points Eumenes | 2 comments | 20 Nov 24 23:53 UTC | HN request time: 0.41s | source
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kbos87 ◴[21 Nov 24 02:14 UTC] No.42200375[source]▶
There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.

For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

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apwell23 ◴[21 Nov 24 07:54 UTC] No.42202077[source]▶
> low dose of Semaglutide

I thought its only approved at standard dose.

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1. cthalupa ◴[21 Nov 24 12:09 UTC] No.42203519[source]▶
There is a dosing schedule for all the GLP-1s, with what is considered the minimal therapeutic dose being several times your initial dose.

However, a lot of people either see results on these initial doses, and plenty of people find them to be effective as maintenance doses.

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2. AuryGlenz ◴[21 Nov 24 15:15 UTC] No.42205083[source]▶
I took it for a bit as a non-overweight person and the minimum dose was absolutely enough for me to have a hard time eating enough to maintain my weight.