Weight-loss drug found to shrink muscle in mice, human cells

There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.

For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

You did not lose 40 pounds of fat while building lean muscle tissue unless you're BOTH relatively new to weightlifting and use PEDs, in which case, the "hysteria" is justified for an average person.

Just the former is likely enough over a 6 month span, even without great genetics. That's only a 1.6lb/week loss. Noob gains can be huge.

A caloric deficit that allows a continuous weight loss of 1.6 lbs a week for 6 months is significant enough to completely wreck your hormonal profile and put you in constant catabolic state, I doubt you would be able to put on any noticeable amount of muscle mass even during your noob gains phase in that context.