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Weight-loss drug found to shrink muscle in mice, human cells

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234 points Eumenes | 2 comments | 20 Nov 24 23:53 UTC | HN request time: 0.427s | source
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kbos87 ◴[21 Nov 24 02:14 UTC] No.42200375[source]▶
There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.

For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

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1. BartjeD ◴[21 Nov 24 04:21 UTC] No.42201081[source]▶
It predicts long term consequences on health. Not immediate ones. You wouldn't have noticed at all. Unless you measured your heart muscle weight.

It's good to work out. Perhaps it offsets any loss.

I get that it's upsetting and might contradict what you think.

At this stage we don't know for sure. It's something you might want to keep in mind. Especially if you take this drug without working out.

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2. peteforde ◴[21 Nov 24 04:56 UTC] No.42201263[source]▶
If someone is taking this medication for the right reasons, the risks of taking it are far lower than those associated with obesity and diabetes.

Also, concern of losing muscle mass on GLP-1 agonists (and diets in general) is well known and typically explained by the responsible MD to the patient.