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372 points Eumenes | 2 comments | | HN request time: 0.508s | source
1. DidYaWipe ◴[] No.42199729[source]
So... could this be a treatment for enlarged hearts?
replies(1): >>42203855 #
2. FollowingTheDao ◴[] No.42203855[source]
Interesting!

People do no realize how wide spread the GLP1 receptors are in the human body. GLPL1R is expressed on all muscles so heart muscle will be effected:

https://pmc.ncbi.nlm.nih.gov/articles/PMC5939638/

https://www.proteinatlas.org/ENSG00000112164-GLP1R/tissue

The way these drugs help loose weight is by increasing cellular activity by stimulating adenylyl cyclase and increased intracellular cAMP levels. It is not that hard and not a msytery to anyone who can think straight about human metabolism.