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Weight-loss drug found to shrink muscle in mice, human cells

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234 points Eumenes | 7 comments | 20 Nov 24 23:53 UTC | HN request time: 0s | source | bottom
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cm2187 ◴[21 Nov 24 00:11 UTC] No.42199591[source]▶
> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle

That's the sort of headlines that smells like bullshit to me.

My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are observing is the effect of a diet. Not sure the diet drug has much to do with it.

Then I went from 133kg to 88kg with these diet drugs. Even though I exercised every day, I am sure I also lost some muscle mass as well, just because I don't have to carry 45kg every time I make a move anymore. Seems logical and would probably be concerned if it was any other way.

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1. denkmoon ◴[21 Nov 24 00:17 UTC] No.42199644[source]▶
god... 133kg down to 88kg, that's like a dream to me. Years of trying to get under 100 by 'traditional' calorie restriction diet & exercise.
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2. throwaway14356 ◴[21 Nov 24 00:28 UTC] No.42199718[source]▶
some fun study sort of concluded that the ratio carbs vs fat and protine is the entire mechanic. fat people who eat almost nothing eat only carbs thin people who can eat huge amounts every day eat a lot of fat and protein. Both eat other things just not as much.
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3. renewiltord ◴[21 Nov 24 00:33 UTC] No.42199745[source]▶
One of my friends has tried many fad diets, etc. and he finally just went and paid cash for a GLP-1 and he's lost a lot of weight and is feeling much better. If I were in that situation, I would just do the same.
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4. twelve40 ◴[21 Nov 24 00:59 UTC] No.42199927[source]▶
bringing it down is not even half the battle, it's what happens next is the more interesting part
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5. turbojet1321 ◴[21 Nov 24 01:22 UTC] No.42200051{3}[source]▶
You keep taking the GLP1 agonist, otherwise you gain the weight you lost.
6. renewiltord ◴[21 Nov 24 02:18 UTC] No.42200413{3}[source]▶
These drugs are like psychedelics. There are lots of non users talking about them like they know them but all they did is read stuff in popular media.

My friend cut usage after he lost weight and finds maintenance easy.

7. throwaway14356 ◴[21 Nov 24 03:12 UTC] No.42200733[source]▶
I really eat a lot. When my gf cooked more and the potato meat ratio changed from 1:3 to 3:1 I immediately started to grow fat. I had her adjust it to 1:1 and started eating lots of sausages and chicken legs between meals. 500g to a kg per day worth of extra food. My body fat declined rapidly.