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Weight-loss drug found to shrink muscle in mice, human cells

(www.ualberta.ca)
234 points Eumenes | 12 comments | 20 Nov 24 23:53 UTC | HN request time: 0.001s | source | bottom
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cm2187 ◴[21 Nov 24 00:11 UTC] No.42199591[source]▶
> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle

That's the sort of headlines that smells like bullshit to me.

My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are observing is the effect of a diet. Not sure the diet drug has much to do with it.

Then I went from 133kg to 88kg with these diet drugs. Even though I exercised every day, I am sure I also lost some muscle mass as well, just because I don't have to carry 45kg every time I make a move anymore. Seems logical and would probably be concerned if it was any other way.

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1. hnthrowaway0328 ◴[21 Nov 24 00:15 UTC] No.42199630[source]▶
Just curious, does your appetite come back whence you cut off the meds?

The only reason I want to lose weight is to eat more freely, won't be useful if I lose my appetite too.

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2. 0xB31B1B ◴[21 Nov 24 00:17 UTC] No.42199641[source]▶
Appetite comes back yes
3. andreareina ◴[21 Nov 24 00:17 UTC] No.42199645[source]▶
It does.
4. xeromal ◴[21 Nov 24 00:21 UTC] No.42199675[source]▶
I saw someone mention that they craved heroin less on ozympic.
5. cm2187 ◴[21 Nov 24 00:22 UTC] No.42199677[source]▶
You don't lose taste, you lose your appetite, which means you can resist the temptation to eat easily, and you feel full very quickly. That doesn't prevent you from eating what you like, but it does help you to not eat too much of it, which I hope is not what you mean by "more freely".

The appetite comes back when you cut the meds, but it's an appetite based on your new weight. But if you then go on a some suggar rampage, you will regain weight and your appetite will grow too.

Those drugs are merely a guard rail to complete a diet successfully, but if people do not change their eating habbits, the same causes will produce the same effects after they cut the meds.

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6. hnthrowaway0328 ◴[21 Nov 24 00:28 UTC] No.42199716[source]▶
Thanks, that's good enough. I have been going to weight loss for over 6 months but I'm stuck between 79 and 80kg. It's a bit difficult to add more weight lifting because I tended to hurt myself, so eat less is better.
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7. andy_ppp ◴[21 Nov 24 00:39 UTC] No.42199796[source]▶
What I’ve found is foods I could usually binge on like pizza I’m quite full on GLP-1 inhibitors and can quite happily stop at half or 2/3 of a pizza. Usually I’d have eaten the whole thing (12” think napoleon style pizza Americans) and want more, refined carbs I never feel full from.
8. andy_ppp ◴[21 Nov 24 00:40 UTC] No.42199807{3}[source]▶
Add walking for 2h per day is the recommended I’ve seen.
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9. throwaway2037 ◴[21 Nov 24 01:32 UTC] No.42200117{3}[source]▶

    > It's a bit difficult to add more weight lifting because I tended to hurt myself
Did you try slightly lower weight and higher reps? It is worth trying as an experiment. Current scientific literature says that 5-30 reps is the ideal range for gaining muscle mass. And, as you said, the relative heaviness of weights to the person makes a big difference for injury risk.
10. vundercind ◴[21 Nov 24 02:03 UTC] No.42200330[source]▶
Experiences vary but I worried I’d, like, not enjoy food on it.

Nope, not a problem. I just get full much faster and am even more prone to simply not eating when I’m busy, than I already was. Not as food-focused when idle, but I still snack a little or whatever.

11. hnthrowaway0328 ◴[21 Nov 24 02:19 UTC] No.42200416{4}[source]▶
Thanks, 2h is a bit too much for me, so what I do is about 3-4 10-12 mins walk-sprint walk reps. Basically half walk (3.5m/h) and half sprint-walk (4.4m/h). I wish I could do more but my joints are not really good.
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12. theendisney ◴[21 Nov 24 02:56 UTC] No.42200645{5}[source]▶
Just walking is better. You get a steady burn. If you do high intensity you burn calories for a good while afterwards. Mild intensity doesnt do much.