I had a domain for a while that people got spam "from" all the time. It had nothing to do with me and there was nothing I could do about it.
Of the "too big to block outright" spam senders, behind Twilio Sendgrid and Weebly, Google is currently #3. Amazon is a close #4. None of the top four currently have useful abuse reporting mechanisms... Sendgrid used to be OK, but they no longer seem to take any action. Google doesn't even accept abuse reports, which is ironic because "does not accept or act upon abuse reports" is criteria for being blocked by Google.
Most spam from Google is fake invoices and 419 scams. This is trivially filtered on my end, which makes it perplexing Google doesn't choose to do so. I can guarantee that exactly 0% of Gmail users sending out renewal invoices for "N0rton Anti-Virus" are legitimate.