If people think this is harassment, no wonder people experience a lot of harassment.
Unless there was more to it the correct answer is along the lines of "yes thankfully" and then a laugh.
I'd recommend a good look in the mirror when looking for the problem in such situations.
Same goes for the thing about trying to discreetly notifying that someone has dirty hands:
Yes, I don't know what is up with Americans and demanding everyone has clean hands at all times, but as long as that is a thing this probably is meant as a favor. Maybe clumsily, but still.
More generally the saying: "when you hear hooves, think horses, not zebras" comes to mind:
If you expect things to be meant funny or helpful (and give people some slack) maybe life becomes a lot less stressful than if everything has to be seen through a lens of gender dynamics.
And if one is known as a reasonable person, I guess people will also take your side if you have to be loud and clear about something, e.g. if it turns out someone wasn't just clumsily trying to be nice or funny.