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286 points amichail | 3 comments | | HN request time: 0.608s | source
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jasonpeacock ◴[] No.41874143[source]
How long does this cure last until the unhealthy diet & lifestyle that originally caused the insulin resistance bring it back again?

It's frustrating, as Type 2 diabetes is 100% manageable through diet. You don't even have to exercise, just eat healthy. Today, with the use of continuous glucose monitors, you have all the data you need to make informed diet decisions - you know exactly what "eat healthy" means for your body.

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sctb ◴[] No.41874297[source]
Not sarcasm: I'm sure it would be frustrating to see so much scientific and commercial effort going into treating TIID pharmacologically when you believe the solution is trivial. But you could also consider all of these developments as evidence that the prescription of "just eat healthy" isn't broadly useful.
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meiraleal ◴[] No.41874422[source]
> But you could also consider all of these developments as evidence that the prescription of "just eat healthy" isn't broadly useful.

As programmers, we usually prefer to remove code to fix a bug than adding patches on top of buggy code. Let's not pretend that the same logic does not apply here.

That's clearly double unhealthy behavior and will bring unintended consequences. Which might be better than the current predicament but still let's not pretend this is not a "monkeypatch".

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1. consteval ◴[] No.41882257[source]
> That's clearly double unhealthy behavior and will bring unintended consequences

Consider: GPL-1 inhibitors are actually root-cause solutions, and diet/exercise are not root cause solutions.

That's because the cause of obesity is not eating. The cause of obesity is a propensity to overeat. The cause begins in your brain and automatic responses, not on the table or the gym.

That's why you and I can eat, be satisfied, and not be obese.

Diet/exercise doesn't address the root cause. It fixes the symptom - obesity. But those people are still addicts, and if they fall off then they're off and will become obese again, much like an alcoholic. This diet "rubber banding" is extremely common.

Ozempic and others address the root cause, by lowering the desire or propensity to eat, perhaps closer to that of someone with a normal brain and normal regulation.

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2. meiraleal ◴[] No.41883711[source]
> That's why you and I can eat, be satisfied, and not be obese.

Who said so?! I have been obese (clinically, BMI) multiple times. And all the time I got back to overweight then normal weight by exercising and eating less (than what I wanted! Because eating until I feel like exploding is so good).

> Consider: GPL-1 inhibitors are actually root-cause solutions, and diet/exercise are not root cause solutions.

False. Overeating is caused by lack of movement and bad diet. There is no point in discuss the rest starting from a completely wrong point.

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3. consteval ◴[] No.41904558[source]
> Overeating is caused by lack of movement and bad diet

Is this some kind of joke? A bad diet doesn't cause overeating - overeating IS the bad diet. Also not moving doesn't cause overeating, because how could it? What, I sit down and suddenly a burrito appears in my hands?

The cause of overeating is a propensity to overconsume, i.e. you have an addiction. Diet and exercise address the SYMPTOMS, but not the ROOT CAUSE. You STILL have an addiction. In the exact same way someone who is sober is STILL an alcoholic.

Because drinking alcohol is not actually the root cause of alcoholism. The root cause is an addiction to alcohol. You can't get rid of the addiction, but you can treat the symptoms - by never drinking, by being sober. But you did not address the root cause.

By my logical analysis, I conclude GLP-1 inhibitors better address the root cause than diet and exercise. To further strengthen my point, you've more or less admitted this by pointed out you've been obese "multiple times". If you had addressed the root cause this would be impossible! But you did not address the root cause but merely the symptoms via diet and exercise. You still had the addiction, so when you slipped you became obese again. This cannot happen while taking a GLP-1 inhibitor because you no longer have the extreme desire to eat. Even when you lost weight, you still had the extreme desire to eat.