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196 points amichail | 3 comments | | HN request time: 0.605s | source
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jasonpeacock ◴[] No.41874143[source]
How long does this cure last until the unhealthy diet & lifestyle that originally caused the insulin resistance bring it back again?

It's frustrating, as Type 2 diabetes is 100% manageable through diet. You don't even have to exercise, just eat healthy. Today, with the use of continuous glucose monitors, you have all the data you need to make informed diet decisions - you know exactly what "eat healthy" means for your body.

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sctb ◴[] No.41874297[source]
Not sarcasm: I'm sure it would be frustrating to see so much scientific and commercial effort going into treating TIID pharmacologically when you believe the solution is trivial. But you could also consider all of these developments as evidence that the prescription of "just eat healthy" isn't broadly useful.
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jasonpeacock ◴[] No.41874379[source]
100% agree, it's a modern cultural problem. We look for drug and technology solutions because "doing the right thing" is hard.
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1. baq ◴[] No.41874478[source]
GLP-1 drugs don’t make you burn fat, they make you eat healthy (or healthier, at least). That’s why they’re so amazingly effective and the reason why is even more amazing - they hack your reward subsystem.
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2. nradov ◴[] No.41874681[source]
GLP-1 drugs seem to increase resting heart rate. I suspect that also increases total daily energy expenditure, although I don't know that we have reliable data on that yet.
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3. rootusrootus ◴[] No.41874769[source]
That can happen, but is not universal. My resting heart rate has been dropping (probably in lock step with my weight), it has not risen one bit since I started taking tirzepatide. And my heart rate variability has been trending up, not down.

Why do you suspect it changes energy expenditure?