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A New Mode of Cancer Treatment

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322 points atomroflbomber | 1 comments | 03 Aug 23 08:12 UTC | HN request time: 0.219s | source
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Metacelsus ◴[03 Aug 23 16:19 UTC] No.36987922[source]▶
Would the Ames test even make sense, given that bacteria don't have PCNA?
replies(1): >>36990134 #
1. flobosg ◴[03 Aug 23 18:55 UTC] No.36990134[source]▶
The compound might have additional mutagenic mechanisms apart from the described PCNA interaction: it could cause direct chemical modifications to DNA, act as an intercalating agent that disrupts DNA replication and/or transcription, etc.