←back to thread

A New Mode of Cancer Treatment

(www.science.org)
322 points atomroflbomber | 2 comments | 03 Aug 23 08:12 UTC | HN request time: 0s | source
1. Metacelsus ◴[03 Aug 23 16:19 UTC] No.36987922[source]▶
Would the Ames test even make sense, given that bacteria don't have PCNA?
replies(1): >>36990134 #
2. flobosg ◴[03 Aug 23 18:55 UTC] No.36990134[source]▶
The compound might have additional mutagenic mechanisms apart from the described PCNA interaction: it could cause direct chemical modifications to DNA, act as an intercalating agent that disrupts DNA replication and/or transcription, etc.