Silicon Valley is trending for like-ability about where Wall Street was in 2008. But of course she should run, as should Zuckerberg, Thiel, Altman etc because it would be a hoot watching them go down in flames.
If Clinton's 9-figure campaign couldn't get a handle on what the average American voter wants from their government, it would be downright hilarious to watch someone from Silicon Valley try. The region is so far out of touch, they aren't even on the same planet.
The problem wasn't Clinton's campaign, it was the candidate; it's amazing that a candidate that widely hated and whose negatives were rock solid from decades of political exposure still managed to get more votes than Trump, who came in with slightly higher negatives, but about whom voters had far less firm opinions.