Silicon Valley is trending for like-ability about where Wall Street was in 2008. But of course she should run, as should Zuckerberg, Thiel, Altman etc because it would be a hoot watching them go down in flames.
If Clinton's 9-figure campaign couldn't get a handle on what the average American voter wants from their government, it would be downright hilarious to watch someone from Silicon Valley try. The region is so far out of touch, they aren't even on the same planet.
You think that the person who created the system that controls most middle-aged Americans news and emotions doesn't have a handle the electorate's feelings?