Turning the clone into the tool required the usual resources of brains, skill, and luck, but it also took years and years of hard graft - Tsien's lab in particular has put an insane amount of work into building an entire rainbow of practically useful fluorescent proteins. I'm sure Prasher would have been only too happy to have bent his shoulder to bear his share of that graft, but sadly, things didn't go that way, and so, in the end, it wasn't him did the work, and it wasn't him who won the prize.
But yeah, poor guy. Academia is an incredibly hard road, and it sheds good people at every level. I was lucky enough that when my scientific career ran out of runway, i had programming to fall back on. Not all of my former colleagues have been so lucky.