Interestingly enough this library doesn't provide grapheme cluster tokenization and/or boundary checking which is one of the most useful primitive for this.
If you’re in control of all data representations in your entire stack, then yes of course, but that’s hardly ever the case and different tradeoffs are made at different times (eg storage in UTF-8 because of efficiency, but in-memory representation in UTF-32 because of speed).
StringZilla added full Unicode case folding in an earlier release, and had a state-of-the-art exact case-sensitive substring search for years. However, doing a full fold of the entire haystack is significantly slower than the new case-insensitive search path.
The key point is that you don’t need to fully normalize the haystack to correctly answer most substring queries. The search algorithm can rule out the vast majority of positions using cheap, SIMD-friendly probes and only apply fold logic on a very small subset of candidates.
I go into the details in the “Ideation & Challenges in Substring Search” section of the article