Ask HN: What hard problems are still underexplored?

Chemistry (Or biology, as an extension of it) simulations. Current tools include Newtonian atom-centered force fields that are fit to a specific situation and lose validity outside it, and quantum computations that are very slow, and don't scale well.

I have a hunch there is something about the underlying physics we are missing, and that we have not hit the endgame of modelling physics at this scale.

I've been experimenting in this space, where might I find a guide for what to build that would be useful to you? I suspect most existing approaches are an order of magnitude slower and harder to use than they need to be.