Trials avoid high risk patients and underestimate drug harms

This is only because society doesn't bear the cost of the natural outcome. If someone with suicidal ideation is excluded from trials on moral grounds and ultimately satisfies those internal cravings, nobody is at fault.

> This is only because society doesn't bear the cost of the natural outcome

Society doesn't bear the cost of someone killing themselves? That can't be what this means, but it's hard for me to read it a different way.

> If someone with suicidal ideation is excluded from trials on moral grounds and ultimately satisfies those internal cravings, nobody is at fault.

If someone with suicidal ideation is included in trials where drugs may INCREASE those ideations and they kill themselves, then the trial is at fault. You're not actually contending that they should be included anyway because they'll probably kill themselves anyway?

I can think of someone who might be at fault.

Then why don't you tell the room who it is?

On the flip side, the drugs may have decreased the ideations. The entire point of it being a trial is that it's unknown.