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Trials avoid high risk patients and underestimate drug harms

(www.nber.org)
174 points bikenaga | 2 comments | 08 Dec 25 19:07 UTC | HN request time: 0s | source
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OutOfHere ◴[08 Dec 25 21:25 UTC] No.46197855[source]▶
Move generally, whenever you read the percentage of patients that are noted as having a particular side effect from a medicine, the real percentage is much higher.
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Aurornis ◴[08 Dec 25 22:47 UTC] No.46198715[source]▶
> whenever you read the percentage of patients that are noted as having a particular side effect from a medicine, the real percentage is much higher.

The patients self-report their own side effects, then the numbers go into the paper.

Are you suggesting the study operators are tampering with numbers before publishing?

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1. OutOfHere ◴[08 Dec 25 23:33 UTC] No.46199185[source]▶
> Are you suggesting the study operators are tampering with numbers before publishing?

No, but did you not read the posted article? Firstly, trials don't select participants unbiasedly. Secondly, many trials are not long enough for the side effects to manifest. Thirdly, I have enough real world experience.

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2. throwawaylaptop ◴[09 Dec 25 00:02 UTC] No.46199488[source]▶
Real world experience doesn't count on HN health articles. If it wasn't documented by a researcher paid via funding from his industry leaders, or a government official trying to fast track his hiring in the public sector for $800k a year, it basically didn't happen.