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55 points arielzj | 3 comments | | HN request time: 0.596s | source
1. Vecr ◴[] No.46198881[source]
This is optimistic, I see "The cryonics people make a mistake in freezing you (how do we know they don't make lots of mistakes?)"[0] and "The current cryonics process is insufficient to preserve everything"[0] resulting of a product 10% already, seemingly matching the questionnaire as well as possible. They say "under ideal conditions" in the survey, so maybe that rules out cracking of brain tissue or ice growth, but that's not the number practitioners want to know about.

[0]: https://www.jefftk.com/p/breaking-down-cryonics-probabilitie... “Principles of Cryopreservation by Vitrification” https://gwern.net/doc/biology/2015-fahy.pdf

replies(1): >>46203498 #
2. arielzj ◴[] No.46203498[source]
...I'm not sure what this is supposed to mean. Asking about ideal conditions is a reasonable starting point for establishing a baseline, and high-quality preservation is definitely something that can be achieved under laboratory conditions with animal models (e.g. https://www.sciencedirect.com/science/article/pii/S001122401...)
replies(1): >>46212647 #
3. Vecr ◴[] No.46212647[source]
Principles of Vitrification (Fahy PDF linked) p. 48 many practitioners think they have vitrified when they have not p. 45 volume changes of vitrifying agents, possibly in a way that avoids detection (very small scale?).

Covers the second term, "freezing" (quibble quibble) speed and delays in the procedure cover the first.

Your team seems not to be trying to maintain either normally solid/fluid tissue maintaining recoverable gradients or vitrification through an entire cycle below the triple point (with just removable or bio-compatible vitrifying mixtures) so your "goal" might be easier. Is the future AI just going to say you didn't do well enough even if you meet your "goal"?

On the other hand if there's never any point in the cycle where any volume is not either recoverable to health or vitrified, all the AI can say is that cryonics doesn't work period.