You can make PS2 games in JavaScript

A similar thing, also using QuickJS, but for the Nintendo Switch: https://github.com/TooTallNate/nx.js (I'm not the author).

Nice, this is similar to what I was wondering about - it looks like it's pretty limited in capability right now (looks like it only supports canvas2d at the moment: https://nxjs.n8.io/runtime/rendering/canvas), but in theory it would allow you to make a layer to convert WebGPU or WebGL games for Switch (ignoring the huge performance drop going from v8 / jit JS engines to QuickJS).