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129 points surprisetalk | 5 comments | | HN request time: 0s | source
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gnatman ◴[] No.45957477[source]
Substituted amphetamines were already very popular in the 1950s.
replies(4): >>45957746 #>>45957886 #>>45957901 #>>45961286 #
1. kragen ◴[] No.45961286[source]
Adderall is just regular amphetamine, not even a substituted amphetamine.
replies(1): >>45961560 #
2. temp0826 ◴[] No.45961560[source]
It's a mix of 4 different amphetamines
replies(1): >>45961620 #
3. kragen ◴[] No.45961620[source]
Two, but those are just the enantiomers dextroamphetamine and levoamphetamine. Neither has any atoms extra or missing. It looks like four amphetamines because those two cationic isomers are in salts with two different anions.
replies(1): >>45962275 #
4. temp0826 ◴[] No.45962275{3}[source]
Each enantiomer exhibits different effects so I don't know if that is relevant. (Even if you count dextroamphetamine sulfate and amphetamine sulfate as one, I'd still probably call it 3 because dextroamphetamine saccharate and amphetamine asparate monohydrate (the other two parts of adderall) do indeed have different forumlas).
replies(1): >>45963502 #
5. kragen ◴[] No.45963502{4}[source]
If you synthesize amphetamine through the usual pathways, as I understand it, you get a racemic mixture, which is what is normally meant by unqualified "amphetamine", and is very close to Adderall. It's true that levoamphetamine is not really active at all in this context.

As I understand it, the aspartate and saccharate still dissociate in solution. If so, there isn't much of a plausible reason to consider them different drugs. If not, they might act more slowly or not at all.

None of this puts Adderall in the class of substituted amphetamines like MDMA or Desoxyn or exotics like ALEPH: https://www.erowid.org/library/books_online/pihkal/pihkal003...