If we get something coming from more than 100 light years away we might not have the technology to respond, and if we do it may not matter anyway if we are at risk of not having a technological civilization anymore 100-200 years forward. So the meaningful actions on those cases may not include answering back.
Then it will be the actual use of that message. Lets assume that we will decide that is a signal from a civilization that is out there. It will be a signal meant for us and for any other civilization that doesn't have the knowledge/culture level as them, meant for giving us a common ground for communicating back, or it will be something that just will tell us that someone intelligent is out there, but no mean to understand it?
So the options are that we find apparently benevolent aliens willing to contact us, or that we find out that someone is out there but no way to communicate/reach them. I think the second scenario is the most probable one, and how our civilization will react if widely enough will change with time, novelty at first and indifference a few years later.