I'm working with JS for already 25 years. Tried all of the frameworks, and continue on doing it. And every time I try something new, the refactoring flow turns most of them into NextJS (if it's very UI rich or customer facing or something very web-oriented), or Vite+React+Tailwind (client) and Hono (backend) if it's more of a tinker toy needing more custom solutions.
The boilerplate with NextJS is cleanest (compared to all the other frameworks) and API is the most straightforward one, and you can safely ignore the vendor lock in. Its just a pretext to hate on NextJS. They all have some kind of a "vendor" lock in. Be it a vendor-or-a-specific-approach-or-whatever-lock-in.
And Vite+React+Hono — simplest to set up for quick experiments, and very powerful with minimal boilerplate. Will probably create a starter for this one, as I have been using this stack quite a lot lately.
EDIT:
You can pretend vanilla JS is all you need, but then your app grows, then you suddenly need types, and state, and more events and their handlers, and SSR or something else. Thus React has been the most stable bet for quite a while for me now.