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Three-Minute Take-Home Test May Identify Symptoms Linked to Alzheimer's Disease

(www.smithsonianmag.com)
116 points pseudolus | 2 comments | 19 Sep 25 19:03 UTC | HN request time: 0.001s | source
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pedalpete ◴[19 Sep 25 22:23 UTC] No.45307457[source]▶
There is a growing body of research showing that increasing slow-wave activity during sleep can improve outcomes, including sleep quality[1], memory, and correlations with amyloid response[2].

Sadly, our latest grant application did not receive funding, but we are supporting other clinical researchers with our technology. Our technology is based on more than a decade of research with 50+ published, peer reviewed studies.

We focus on sleep directly rather than the disease, which means people do not have to wait years for regulatory approvals before they can feel day-to-day benefits.

For those curious about learning more, our approach and links to additional research are on our website https://affectablesleep.com .

Mild-to-moderate Alzheimer’s changes in sleep https://doi.org/10.1016/j.jagp.2024.07.002

Slow-wave activity, memory, and amyloid response https://doi.org/10.1093/ageing/afad228

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impendia ◴[20 Sep 25 16:30 UTC] No.45314795[source]▶
I have been on your mailing list for time, and at least semi-seriously thought about buying one.

Like other readers, I saw the subscription business and got put off.

Especially since it seems that every company eventually either "enshittifies" or goes on an "incredible journey".

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pedalpete ◴[20 Sep 25 21:42 UTC] No.45317836[source]▶
Well, start-ups are an incredible journey! :)

We have no aim to "enshittify", I'm actually not sure what an incredible journey is? Can you elaborate on who has gone on such incredible journey's?

I wonder if some of the enshitiffication is a result of investor demands (as another comment alluded to).

We're doing our best to bootstrap Affectable. Bootstrapping a neurotech hardware start-up is not easy, and it's a bit of a miracle we've mostly managed so far.

Thanks for your input, and your early support. I'd be keen to know if there were other details you'd like to hear about on our mailing list.

We'll keep reviewing our pricing model based on feedback. We do appreciate you taking the time, and for your consideration.

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impendia ◴[21 Sep 25 02:23 UTC] No.45319462[source]▶
I'm referring to this website:

https://ourincrediblejourney.tumblr.com/

Blog posts from startups who get acquired by big companies, talking about what an incredible journey their startup has been, and thanking their customers and promising ongoing support for their products. And then breaking these promises soon after.

And no one aims to enshittify, but my understanding is that pressure from investors eventually becomes louder than that from customers. (Although perhaps less so in your case, as you say you're bootstrapping.)

If you have a subscription model, you're asking me to trust you over the long term. But, if I understand your product correctly, there's no technical reason why I need to have an ongoing relationship with you or even an internet connection to use your product. Those are apparently business decisions. And I'm afraid those are decisions which lead me to trust you less.

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pedalpete ◴[21 Sep 25 03:29 UTC] No.45319790[source]▶
Oh, I hadn't heard of that tumblr.

The reality is that without a subscription, the product would not be viable. We would either have to charge nearly double upfront, or risk not being around to support it in a few years.

The subscription lets us keep the starting cost lower, which makes the tech inaccessible for many people. The subscription balances that out, and it also means we can keep supporting the system over time instead of leaving people stranded.

In a sense, it is actually what makes the long-term viability and hopefully trust possible.

That's how we view it.

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1. impendia ◴[21 Sep 25 04:11 UTC] No.45319994[source]▶
You have the disadvantage of operating in a space where a lot of people and companies claim a lot of different things, and where cause and effect is maddeningly difficult to sort out.

For example, if you read Slate Star Codex, you can find all manner of posts discussing how psych meds are produced and brought to market, how they can behave in unpredictable fashion, and why claims made by the pharmaceutical industry should be regarded with a healthy dose of distrust. But its author is a trained psychiatrist, and he'd be the first to tell you that psych meds do indeed work.

Personally, I've dealt with sleep issues for years with reasonably consistent symptoms. I read various books and tried CBT, therapy, and a variety of meds. A lot of this seemed to either do nothing, or else have strange effects. Eventually I tried some med that got terrible reviews online, which to my surprise pretty much solved my problem overnight. Now I'm overseas for several months without access to this medication, and to my complete surprise my sleep has been fine. Why? Will things stay this way? I wish I could tell you!!

All this is to say, for your target market, suspicion and distrust will often be par for the course. Please don't take it personally :)

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2. pedalpete ◴[21 Sep 25 05:56 UTC] No.45320400[source]▶
I hadn't heard of Slate Star Codex, I'll check this out.

Not taking it personally at all!

I'm a life-long chronic insomniac, which is how I got into this.

My first reaction wasn't "I'm going to solve this problem", it was

1) is this slow-wave enhancement even real 2) will anyone believe it 3) who is it for? How do we prove it?

I had some confidence in slow-wave enhancement because Philips did a bunch of research in this space and tried to launch a product and failed.

But the researchers that worked with Philips were at University of Sydney (where we work) and Melbourne, so I had access to some of the top researchers in the world.

Also, one of the first researchers I spoke to said he was amazed by the technology, but then I discovered he secretly hated it. He didn't make excuses for why it wouldn't work. He said it did, but made excuses for why we couldn't do it. Why it wasn't safe (which has been proven wrong). That made me go "wow! This guy could have said it doesn't work, but he didn't. He said it works, but we don't know the impact on respiratory function, immune function, etc etc. " That was a powerful moment for me.

Then I spoke to some local VCs and med investors I know, thinking, I'm going to need funding, will they just ignore us? One said "this is exactly the sort of thing he looks for". Then they ghosted us, but I sold my other start-up and we funded this :)

Lastly, the who is it for....this is the one Philips really struggled with. I think it's the biggest challenge for us.

You mentioned your insomnia. We're not an insomnia device. But everyone hears "better sleep" and thinks fall asleep faster, sleep longer. That is a difficult pattern to break out of.

I still have insomnia. I'll tell you what is not the cure...bootstrapping a neurotech hardware start-up! :)

My belief is that if we stay true and honest about our capabilities, focus on the people we can help, and change the story about sleep.

From that base, we can look to continue to expand and help others.