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Three-Minute Take-Home Test May Identify Symptoms Linked to Alzheimer's Disease

(www.smithsonianmag.com)
104 points pseudolus | 2 comments | 19 Sep 25 19:03 UTC | HN request time: 0.396s | source
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pedalpete ◴[19 Sep 25 22:23 UTC] No.45307457[source]▶
There is a growing body of research showing that increasing slow-wave activity during sleep can improve outcomes, including sleep quality[1], memory, and correlations with amyloid response[2].

Sadly, our latest grant application did not receive funding, but we are supporting other clinical researchers with our technology. Our technology is based on more than a decade of research with 50+ published, peer reviewed studies.

We focus on sleep directly rather than the disease, which means people do not have to wait years for regulatory approvals before they can feel day-to-day benefits.

For those curious about learning more, our approach and links to additional research are on our website https://affectablesleep.com .

Mild-to-moderate Alzheimer’s changes in sleep https://doi.org/10.1016/j.jagp.2024.07.002

Slow-wave activity, memory, and amyloid response https://doi.org/10.1093/ageing/afad228

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ionwake ◴[20 Sep 25 06:43 UTC] No.45311025[source]▶
really cool Im sorry to hear you didnt get funding. I dont know much but isnt the problem related to what causes the build up in teh first place? wasnt it scarring or something?
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1. pedalpete ◴[20 Sep 25 07:36 UTC] No.45311301[source]▶
Thanks. We're used to not getting funding. It's part of the journey as a start-up and in research.

The build-up isn't scarring. It's misfolded proteins in the brain which stick in places they shouldn't and the glymphatic system which flushes cerebrospinal fluid through the brain removes the build-up of these protiens.

If you have poor sleep or lack of sleep, these proteins don't get removed and that build-up interferes and disrupts the firing of neurons.

Alzheimer's drugs are able to help remove the build-up, but unfortunately are not able to repair the damage. That's why they only slow progression of the disease, not treat it.

If slow-wave enhancement lives up to the potential, it would likely also only be preventative. It would be surprising if it was able to treat AD.

If you want to know more, a comment in this post has what I think may be the most thorough breakdown of AD. https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...

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2. ionwake ◴[20 Sep 25 07:49 UTC] No.45311353[source]▶
Great stuff thank you!