And suddenly you can start playing with distributed software, even though it's running on a single machine. For resiliency tests you can unplug one machine at a time with a single click. It will annihilate a Pi cluster in Perf/W as well, and you don't have to assemble a complex web of components to make it work. Just a single CPU, motherboard, m.2 SSD, and two sticks of RAM.
Naturally, using a high core count machine without virtualization will get you best overall Perf/W in most benchmarks. What's also important but often not highlighted in benchmarks in Idle W if you'd like to keep your cluster running, and only use it occasionally.