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Three-Minute Take-Home Test May Identify Symptoms Linked to Alzheimer's Disease

(www.smithsonianmag.com)
108 points pseudolus | 3 comments | 19 Sep 25 19:03 UTC | HN request time: 0.85s | source
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pedalpete ◴[19 Sep 25 22:23 UTC] No.45307457[source]▶
There is a growing body of research showing that increasing slow-wave activity during sleep can improve outcomes, including sleep quality[1], memory, and correlations with amyloid response[2].

Sadly, our latest grant application did not receive funding, but we are supporting other clinical researchers with our technology. Our technology is based on more than a decade of research with 50+ published, peer reviewed studies.

We focus on sleep directly rather than the disease, which means people do not have to wait years for regulatory approvals before they can feel day-to-day benefits.

For those curious about learning more, our approach and links to additional research are on our website https://affectablesleep.com .

Mild-to-moderate Alzheimer’s changes in sleep https://doi.org/10.1016/j.jagp.2024.07.002

Slow-wave activity, memory, and amyloid response https://doi.org/10.1093/ageing/afad228

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DaveZale ◴[19 Sep 25 23:08 UTC] No.45307873[source]▶
yes, poor sleep quality leads to bad days, bad days lead to more bad sleep, it is a downward spiral and may impact many of us in our prime years, too.

All the best on your research and funding. Quality sleep has been undervalued, especially among work cultures that value overachieving at the expense of personal health.

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1. tootie ◴[20 Sep 25 00:50 UTC] No.45308660[source]▶
I have narcolepsy and it's hard to describe what an absolute fog I was in for years before diagnosis. The current best treatment is a powerful depressant taken at bed time and again middle of the night to induce deep sleep.
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2. pedalpete ◴[20 Sep 25 02:24 UTC] No.45309624[source]▶
Is that gabapentin? Or is there something else that is the go to these days?

There was a comment on reddit a few days ago from someone with narcolepsy who was looking for a sleep tracker.

Sadly, our technology does not "induce" deep sleep.

It is suspected that the reason the Alzheimer's study showed such an increase in deep sleep was due to decreased cortisol as a result of stimulation, but that is just a theory at this point.

Studies do show a decrease in night-time cortisol (https://doi.org/10.1038/s41467-017-02170-3) early in the night during stimulation.

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3. tootie ◴[20 Sep 25 04:00 UTC] No.45310235[source]▶
Sodium oxybate. And yeah most commercial sleep trackers are not going to work for someone with such disordered sleep. There have been retail EEGs available but they never catch on.